DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and Sox21b

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001261829.1	Gene:	Sox21b / 39569	FlyBaseID:	FBgn0042630	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	479	Identity:	132/479 - (27%)
Similarity:	193/479 - (40%)	Gaps:	125/479 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 IQRRHPAPKADSTPHTLPPFSPSPSPASSPSPAPA-QT-------------PGAQKTQSQAAITH 87
            :.:.|||  .....|:.||.|.|.:...|.|.|.: ||             .||......||.:|
  Fly   121 LHQHHPA--GQQQQHSQPPVSSSSTSHHSQSQALSHQTHSNGSSQLGGGSASGAGSVAGGAANSH 183

  Fly    88 PAAVASPSAPVAAAAPKTPKTPEPRSTHTHTHTHSQHFSPPPRESEMDGERSPSHSGHEM--TLS 150
            .:|.||.|...||||             .|.|.:||              .||..:.|:.  :|.
  Fly   184 HSAPASSSVMAAAAA-------------AHLHHNSQ--------------ASPISNLHQNMGSLM 221

  Fly   151 MDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNA 215
            ..|..:|.||.|..:          ...||:.:..|||||||||||||:::||||.:..|.:||:
  Fly   222 NSGSSASDVFFSLMI----------QNTTKRQNEEHIKRPMNAFMVWSRLQRRKIAQDNPKMHNS 276

  Fly   216 EISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQKKQTR---------------- 264
            ||||.||..|:||::::|:|:|.||::||.:||.|:|:|||||::|...
  Fly   277 EISKRLGAEWKLLTEEEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKALRRDGYPYPMPYPSVP 341

  Fly   265 --------SPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTTAGRKSK----RSTSTCQSGS 317
                    :||...|...|......:.....:...||.|    |.:|:..|    ||:....|..
  Fly   342 VEALRAGITPGYFAPGPTAAAYHLGSHLGQTSTPTTTQA----TLSGQMDKFALERSSYLSNSSQ 402

  Fly   318 ASKRLRNDSGDTSSKPKYEVKMESAEQLNSADIILPSADNLISYQSSEYLPLSTLSNADCDEKLH 382
            ||...........:|..::.||......|.|                  ..:|.:..|......|
  Fly   403 ASAYSAYLDPSVLTKAYFDSKMYQDRAANYA------------------FDISKIYGAQQHAAAH 449

  Fly   383 SELSSGPLESRENLSEVVNRFLPLFLGGNEDSQLGVSSLTQSQHNQSDPTAGLMDNISDISPIND 447
            .:......:.::...:      .|.|.|...|..|.|:   |.|| ::.::||.|.  |.:|
  Fly   450 HQQQQQQQQQQQQQQQ------QLLLSGGGGSGGGGSA---SSHN-NNSSSGLDDR--DATP--- 499

  Fly   448 REELTEEVMRYLPYLEVNPSSDGL 471
              :|  |.:...|:|. :||..||
  Fly   500 --QL--EAVESKPHLH-SPSDVGL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	42/70 (60%)
Sox21b	NP_001261829.1	SOX-TCF_HMG-box	247..318	CDD:238684	42/70 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451320
Domainoid	1	1.000	49	1.000	Domainoid score	I4418
eggNOG	1	0.900	-	-		E1_KOG0527
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.820