DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and sox4b

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_957195.1	Gene:	sox4b / 393875	ZFINID:	ZDB-GENE-040426-1274	Length:	342	Species:	Danio rerio

Alignment Length:	396	Identity:	125/396 - (31%)
Similarity:	173/396 - (43%)	Gaps:	105/396 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 ERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSP-------GHIKRPMNAF 194
            :||.|.|.   ....|..||..:...|...  |.:|.|.|:..:|.:|       ||||||||||
Zfish     3 QRSSSSSA---LFDGDSSDSGALDLDAHAA--SPSPGSTASGGEKLNPGWCKTASGHIKRPMNAF 62

  Fly   195 MVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQ 259
            |||||:|||||.|::||:|||||||.||:||:||...||.|:|.|||:||..||.:||:|||||:
Zfish    63 MVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDGDKIPFIREAERLRLKHMADYPDYKYRPR 127

  Fly   260 KKQTRSPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTTAGRKSKRSTSTCQSGSASKRLRN 324
            || .:|.|| ||::                               |...|..:.:..||.|..:.
Zfish   128 KK-VKSSGS-KPSE-------------------------------KLSISKPSSKKRSAGKPHKK 159

  Fly   325 DSGDTSSKPKYEVKMESAEQLNSADIILPSAD---NLISYQSSE-----YLPLSTLSNADCDEKL 381
            :.|.......|:.|        :|.::..|.:   .|..:.||.     .:|.|...::..|
Zfish   160 EPGPADHHSLYKAK--------AAPVVKQSPEKKKRLYIFSSSSSPSPAAVPASPTLSSSAD--- 213

  Fly   382 HSELSSGPLESRENLSEVVNRFLPLFLGGNEDSQLGVSSLTQSQHNQSDPT--AGLMDNISDISP 444
                :|.||...|:.|.          .|.||:.   :..|.|......||  |....:.|..|.
Zfish   214 ----TSDPLSLYEDASG----------SGKEDAD---TRYTGSSMRAPSPTPSAAHSSSSSQFSS 261

  Fly   445 INDREELTEEVMRYLPYLEVN--PSSDGLTLKVESSSLLGKPLNEPVFDSEDNIVNDANLHSASH 507
            .:| ||..::.      |:.|  |..|.::|....||:|.:.. :..|||           .|||
Zfish   262 SSD-EEPDDDA------LDANTSPGFDSMSLGSIGSSVLDRDF-DMHFDS-----------GASH 307

  Fly   508 -QIPPY 512
             :.|.|
Zfish   308 FEFPDY 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	50/70 (71%)
sox4b	NP_957195.1	SOX-TCF_HMG-box	54..125	CDD:238684	50/70 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582390
Domainoid	1	1.000	109	1.000	Domainoid score	I6276
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm25639
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030