DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and SOX8

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_055402.2	Gene:	SOX8 / 30812	HGNCID:	11203	Length:	446	Species:	Homo sapiens

Alignment Length:	359	Identity:	91/359 - (25%)
Similarity:	145/359 - (40%)	Gaps:	109/359 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 STPHTLPPFSPSPSPAS------SPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAAAPKTP 106
            |...:.||.|||.:.:|      |.|.|| .:|...:...:|.:....|...|
Human     5 SEARSQPPCSPSGTASSMSHVEDSDSDAP-PSPAGSEGLGRAGVAVGGARGDP------------ 56

  Fly   107 KTPEPRSTHTHTHTHSQHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSST 171
                                     :|...||.|:.....::..:.|.|.|||    .:||....
Human    57 -------------------------AEAADERFPACIRDAVSQVLKGYDWSLV----PMPVRGGG 92

  Fly   172 PYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPY 236
              ..|.:.|.    |:||||||||||:|..|||:.::.|.|||||:||.||:.|:|||:.:|:|:
Human    93 --GGALKAKP----HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPF 151

  Fly   237 IIEAEKLRKLHMIEYPNYKYRPQKKQTRSPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTT 301
            :.|||:||..|..::|:|||:|:::::...|    :.|:|                    :|...
Human   152 VEEAERLRVQHKKDHPDYKYQPRRRKSAKAG----HSDSD--------------------SGAEL 192

  Fly   302 AGRKSKRSTSTCQSGSASKRLRND-SGDTSSKP---------------KYEVKMESAEQLNS--- 347
            .......:....::|........| :|.|...|               |.|:|:|....::|
Human   193 GPHPGGGAVYKAEAGLGDGHHHGDHTGQTHGPPTPPTTPKTELQQAGAKPELKLEGRRPVDSGRQ 257

  Fly   348 ------ADI------ILPSADNLISYQSSEYLPL 369
                  .||      ::.:.|....::..:||||
Human   258 NIDFSNVDISELSSEVMGTMDAFDVHEFDQYLPL 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	40/70 (57%)
SOX8	NP_055402.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		15/90 (17%)
		Sox_N	18..89	CDD:315171	19/112 (17%)
		Dimerization (DIM). /evidence=ECO:0000303\|PubMed:31194875	58..100		12/47 (26%)
		SOX-TCF_HMG-box	101..171	CDD:238684	39/69 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..259		24/127 (19%)
		Transactivation domain (TAM). /evidence=ECO:0000303\|PubMed:31194875	224..298		13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..378
		Transactivation domain (TAC). /evidence=ECO:0000303\|PubMed:31194875	335..446
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..446
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148477
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740