DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and Lpxn

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_038964643.1	Gene:	Lpxn / 293783	RGDID:	1304981	Length:	398	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	77/409 - (18%)
Similarity:	124/409 - (30%)	Gaps:	123/409 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 DSGDTSS--------KPKYEVKME---------------SAEQLNSADIILPSADNLISYQSSEY 366
            ||.|.|:        :|..|.|:.               ..:.:.:.:|..|:..:.:.......
  Rat    30 DSEDYSNPVSCCLDQQPTQESKLPQTPKTLSTQGNTSPLKVQLVYTTNIQEPNVYSEVQEPKQSV 94

  Fly   367 LPLSTLSNADCDE------KLHSELSSGPLESRENLSEVVNR--FLPLFLGGNED--SQLGVSSL 421
            ||..|.:.|..||      :|.:::|.....||:.|.:..:.  .|...|||.|.  ..||::::
  Rat    95 LPPKTSAAAQLDELMAHLNELQAKVSVKADASRKPLPDKQDHKASLDSMLGGLEQELQDLGIATV 159

  Fly   422 TQSQHNQS--DPTAGLMDNISDIS--P-----INDREELTEEVMRYLPYLEVNP----SSDGLTL 473
            .:. |..|  .|.||.:.:....|  |     .:.:|||...     |:.|.|.    |.|...|
  Rat   160 PKG-HCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEELGSS-----PFFERNGLAYCSKDYHHL 218

  Fly   474 KVESSSLLGKPLNEPVFDSED--------------NIVNDANLHSASHQIPPYV-PDSHDCFAED 523
            .....:....|:.:.|..:.:              .:......|....:  ||. .|....|:..
  Rat   219 FSPRCAYCAAPITDKVLTAMNKTWHPEHFFCSHCGEVFGAEGFHEKDKK--PYCRKDFLAMFSPK 281

  Fly   524 CGGDSSSHQVEFEVVRPQTVTMTMTCTLPYGGPDAGHTTFQADDFNAIPSAAEDSECSILTTSNS 588
            |||                      |..|.           .:::.:..:.....||.:.....|
  Rat   282 CGG----------------------CNRPV-----------LENYLSAMNTVWHPECFVCGDCFS 313

  Fly   589 PQIGFNGSSFVEADA-----------IGSTCTYAQQDYTGSVIETHNDLNYAAHDNNGALLAYTF 642
               .|:..||.|.|.           .|:.|....|..||..|.......:..|    .:.|:..
  Rat   314 ---SFSSGSFFELDGRPFCELHYHHRRGTLCHDCGQPITGRCISAMGHKFHPEH----FVCAFCL 371

  Fly   643 EDLPPQPTGSHLEFNTNKY 661
            ..|   |.|...|.|...|
  Rat   372 TQL---PKGIFKEQNNKTY 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684
Lpxn	XP_038964643.1	LIM1_Leupaxin	162..216	CDD:188790	15/59 (25%)
		LIM	223..274	CDD:413332	5/52 (10%)
		LIM	282..334	CDD:413332	13/87 (15%)
		LIM4_Paxillin_like	341..392	CDD:188725	13/54 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900