DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and Meiosin

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001357740.1	Gene:	Meiosin / 243866	MGIID:	3647482	Length:	589	Species:	Mus musculus

Alignment Length:	311	Identity:	56/311 - (18%)
Similarity:	109/311 - (35%)	Gaps:	84/311 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DSTPHTLPPFSPSPSPASSPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAAAPKTPKT--- 108
            :|:|.|....||.....||..|.     |....||..::.|.....|.:..|.:....:.::
Mouse   335 ESSPATCEVESPQEKEVSSEGPT-----GPPNFQSSVSLDHCYLSLSENVKVLSNCGSSSESTDT 394

  Fly   109 ------PEPRSTHTHTHTHSQHFSPPP---RESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSAR 164
                  .|.|...|:...........|   :::..:|.::.|....:.|.:..|..|.|...|.:
Mouse   395 ESLWGQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKK 459

  Fly   165 V-PVNSSTPYSDATRTKKHSPGHIKRP-MNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQL 227
            : .|.:|........::|..||.:|:. :|.|:::.:|.|::.....|...:...:|:|.:.|:.
Mouse   460 IKKVQASQGPVKPKDSRKACPGQVKKKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRG 524

  Fly   228 LSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQKKQTRSPGSLKPNQDADGCEARNDTTNNNNSLT 292
            ::.::|:||..:|.:.                                         :..||.:.
Mouse   525 MTLEEKKPYCTKARRF-----------------------------------------SRQNNRIV 548

  Fly   293 TLAINGTTTAGRKSKRSTSTCQSGSASKRLRNDSGDTSSKPKYEVKMESAE 343
                        |.:.|:|           .:|.|:| .||.|::..|.|:
Mouse   549 ------------KQENSSS-----------EDDDGET-PKPFYQLLAEKAQ 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	13/71 (18%)
Meiosin	NP_001357740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	14..27
		bHLH_SF	24..73	CDD:412148
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	28..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..191
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363		6/25 (24%)
		NHP6B	416..>539	CDD:227935	26/122 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..457		6/34 (18%)
		HMG-box	484..539	CDD:238037	13/54 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..566		9/45 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900