DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and Ldb3

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_036048.3	Gene:	Ldb3 / 24131	MGIID:	1344412	Length:	723	Species:	Mus musculus

Alignment Length:	328	Identity:	75/328 - (22%)
Similarity:	111/328 - (33%)	Gaps:	125/328 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KPNQATTEPPLSLRPGTVPTVPATTPARPATITIQRRHPAPKADSTPHTLPPFSPSPSPASSPSP 68
            ||...||   .|:||.....|||::.:           |:|.|:.:|   .|::|||:||.:|||
Mouse   390 KPRVVTT---ASIRPSVYQPVPASSYS-----------PSPGANYSP---TPYTPSPAPAYTPSP 437

  Fly    69 APAQTPGAQKTQSQAAITHPAAVASPS-APVAAAAPKTPKTPEPRSTHT-------------HTH 119
            ||..||.            ||...||| ||....:|....||.|.:.::             ...
Mouse   438 APTYTPS------------PAPTYSPSPAPAYTPSPAPNYTPTPSAAYSGGPSESASRPPWVTDD 490

  Fly   120 THSQHFSPPPRESEMDGERSP------SHSGHEMTLSMDGIDSSLVFGSA-RVPVNSSTPYSDAT 177
            :.||.|:|....:.:..:..|      :.:|.::|....|     .|..| |.|.:|.||...
Mouse   491 SFSQKFAPGKSTTTVSKQTLPRGAPAYNPTGPQVTPLARG-----TFQRAERFPASSRTPLCG-- 548

  Fly   178 RTKKHSPGHIKRPMNAFMV-----WS-------------------QMERRKICERTPDLHNA--- 215
                |....|:.|   |:|     |.                   :.:....|||..:...|
Mouse   549 ----HCNNVIRGP---FLVAMGRSWHPEEFNCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPIC 606

  Fly   216 ---------EISKELGRRW----------------QLLSKDDKQPYIIEAEK------LRKLHMI 249
                     |:...|.:.|                .|...:|.:||   .||      ..|.|..
Mouse   607 AKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPY---CEKDYINLFSTKCHGC 668

  Fly   250 EYP 252
            ::|
Mouse   669 DFP 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	21/125 (17%)
Ldb3	NP_036048.3	PDZ_signaling	5..81	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..193
		DUF4749	191..293	CDD:374237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..423		14/49 (29%)
		PHA03247	<378..528	CDD:223021	45/166 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..525		23/100 (23%)
		LIM1_ZASP_Cypher	547..598	CDD:188838	9/59 (15%)
		LIM2_Enigma_like	606..657	CDD:188748	9/53 (17%)
		LIM3_ZASP_Cypher	665..719	CDD:188844	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900