Protein Alignment Sox14 and Sry

DIOPT Version :10

• Sequence 1: NP_476894.1
• Gene: Sox14 / 37822
• FlyBaseID: FBgn0005612
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_035694.1
• Gene: Sry / 21674
• MGIID: 98660
• Length: 395
• Species: Mus musculus
• Alignment Length: 89
• Identity: 45/89 - (50%)
• Similarity: 67/89 - (75%)
• Gaps: 2/89 - (2%)

  Fly   185 GHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMI 249
            ||:|||||||||||:.||.|:.::.|.:.|.||||:||.||:.|::.:|:|:..||::|:.||..
Mouse     3 GHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKILHRE 67

  Fly   250 EYPNYKYRPQK--KQTRSPGSLKP 271
            :||||||:|.:  |.::..|.|:|
Mouse    68 KYPNYKYQPHRRAKVSQRSGILQP 91

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_476894.1	HMG-box_SoxC	186..261	CDD:438838	40/76 (53%)
Sry	NP_035694.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000250|UniProtKB:Q05066	4..81		40/76 (53%)
		HMG-box_SoxA_SoxB_SoxG	4..79	CDD:438837	40/74 (54%)
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066	6..22		13/15 (87%)
		Sufficient for interaction with EP300. /evidence=ECO:0000250|UniProtKB:Q05066	52..84		14/31 (45%)
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066	75..81		1/5 (20%)
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269|PubMed:15469996	92..144		45/89 (51%)
		Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000269|PubMed:16166090	94..138
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..361