Protein Alignment Sox14 and Sox9

DIOPT Version :10

• Sequence 1: NP_476894.1
• Gene: Sox14 / 37822
• FlyBaseID: FBgn0005612
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_035578.3
• Gene: Sox9 / 20682
• MGIID: 98371
• Length: 507
• Species: Mus musculus
• Alignment Length: 637
• Identity: 133/637 - (20%)
• Similarity: 215/637 - (33%)
• Gaps: 237/637 - (37%)

  Fly    53 LPPF-----------SPSPSPASSPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAAAPKTP 106
            |.||           |.:|||..|...|.:..|....:.::           .:.|.....||
Mouse     4 LDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTE-----------NTRPQENTFPK-- 55

  Fly   107 KTPEPRSTHTHTHTHSQHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSST 171
                               ..|..:.|.:.::.|......::..:.|.|.:||  ...|.||.|:
Mouse    56 -------------------GEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLV--PMPVRVNGSS 99

  Fly   172 PYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPY 236
                     |:.| |:||||||||||:|..|||:.::.|.|||||:||.||:.|:||::.:|:|:
Mouse   100 ---------KNKP-HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPF 154

  Fly   237 IIEAEKLRKLHMIEYPNYKYRPQKKQTRSPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTT 301
            :.|||:||..|..::|:|||:|::::     |:| |..|:..||...|..:.|::
Mouse   155 VEEAERLRVQHKKDHPDYKYQPRRRK-----SVK-NGQAEAEEATEQTHISPNAI---------- 203

  Fly   302 AGRKSKRSTSTCQSGSASKRLRNDSGDTSSKPKYEVKMESAEQLNSADIILPSADNLISYQSSEY 366
                             .|.|:.||..:||              ..:::..|..
Mouse   204 -----------------FKALQADSPHSSS--------------GMSEVHSPGE----------- 226

  Fly   367 LPLSTLSNADCDEKLHSELSSGP--------LESRENLSEVVNRFLPLFLGGNE------DSQLG 417
                           ||..|.||        .:.:....::.....||..||.:      |..:|
Mouse   227 ---------------HSGQSQGPPTPPTTPKTDVQAGKVDLKREGRPLAEGGRQPPIDFRDVDIG 276

  Fly   418 VSSLTQSQHNQSDPTAGLMDNISDISPINDREELTEEVMRYLPYLEVN-----PSSDGLTLKVES 477
            ..|               .|.||:|.        |.:|..:..||..|     |::.|......|
Mouse   277 ELS---------------SDVISNIE--------TFDVNEFDQYLPPNGHPGVPATHGQVTYTGS 318

  Fly   478 ---SSLLGKPLNEPVFDSEDNIVNDANLHSASHQIPPYVPDSHDCFAEDCGGDSSSHQVEFEVVR 539
               ||....|            ....::..:..|.||..|..
Mouse   319 YGISSTAPTP------------ATAGHVWMSKQQAPPPPPQQ----------------------- 348

  Fly   540 PQTVTMTMTCTLPYGGPDAGHTTFQADDFNAIPSAAEDSECSILTTSNSPQIGFNGSSFVEADAI 604
                        |...|.|.....|.......|.|.:..:...|||.:| :.|.:..:.::.:.:
Mouse   349 ------------PPQAPQAPQAPPQQQAPPQQPQAPQQQQAHTLTTLSS-EPGQSQRTHIKTEQL 400

  Fly   605 GSTCTYAQQDYTGSVIE----------------THNDLNYAAHDNNGALLAY 640
            ..:....||.::...|.                |.:..:||.|.|:|:..::
Mouse   401 SPSHYSEQQQHSPQQISYSPFNLPHYSPSYPPITRSQYDYADHQNSGSYYSH 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_476894.1	HMG-box_SoxC	186..261	CDD:438838	41/74 (55%)
Sox9	NP_035578.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67		15/94 (16%)
		Sox_N	22..94	CDD:463586	16/105 (15%)
		Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P48436	63..103		11/50 (22%)
		PQA. /evidence=ECO:0000250|UniProtKB:P48436	63..103		11/50 (22%)
		HMG-box_SoxE	104..178	CDD:438840	41/73 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..250		28/162 (17%)
		Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P48436	224..307		22/131 (17%)
		9aaTAD 1. /evidence=ECO:0000250|UniProtKB:P48436	275..284		3/23 (13%)
		9aaTAD 2. /evidence=ECO:0000250|UniProtKB:P48436	290..298		1/7 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..429		18/129 (14%)
		Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P48436	392..507		9/61 (15%)
		9aaTAD 3. /evidence=ECO:0000250|UniProtKB:P48436	458..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..507