DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and Sox9

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_035578.3	Gene:	Sox9 / 20682	MGIID:	98371	Length:	507	Species:	Mus musculus

Alignment Length:	637	Identity:	133/637 - (20%)
Similarity:	215/637 - (33%)	Gaps:	237/637 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LPPF-----------SPSPSPASSPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAAAPKTP 106
            |.||           |.:|||..|...|.:..|....:.::           .:.|.....||
Mouse     4 LDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTE-----------NTRPQENTFPK-- 55

  Fly   107 KTPEPRSTHTHTHTHSQHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSST 171
                               ..|..:.|.:.::.|......::..:.|.|.:||  ...|.||.|:
Mouse    56 -------------------GEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLV--PMPVRVNGSS 99

  Fly   172 PYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPY 236
                     |:.| |:||||||||||:|..|||:.::.|.|||||:||.||:.|:||::.:|:|:
Mouse   100 ---------KNKP-HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPF 154

  Fly   237 IIEAEKLRKLHMIEYPNYKYRPQKKQTRSPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTT 301
            :.|||:||..|..::|:|||:|::::     |:| |..|:..||...|..:.|::
Mouse   155 VEEAERLRVQHKKDHPDYKYQPRRRK-----SVK-NGQAEAEEATEQTHISPNAI---------- 203

  Fly   302 AGRKSKRSTSTCQSGSASKRLRNDSGDTSSKPKYEVKMESAEQLNSADIILPSADNLISYQSSEY 366
                             .|.|:.||..:||              ..:::..|..
Mouse   204 -----------------FKALQADSPHSSS--------------GMSEVHSPGE----------- 226

  Fly   367 LPLSTLSNADCDEKLHSELSSGP--------LESRENLSEVVNRFLPLFLGGNE------DSQLG 417
                           ||..|.||        .:.:....::.....||..||.:      |..:|
Mouse   227 ---------------HSGQSQGPPTPPTTPKTDVQAGKVDLKREGRPLAEGGRQPPIDFRDVDIG 276

  Fly   418 VSSLTQSQHNQSDPTAGLMDNISDISPINDREELTEEVMRYLPYLEVN-----PSSDGLTLKVES 477
            ..|               .|.||:|.        |.:|..:..||..|     |::.|......|
Mouse   277 ELS---------------SDVISNIE--------TFDVNEFDQYLPPNGHPGVPATHGQVTYTGS 318

  Fly   478 ---SSLLGKPLNEPVFDSEDNIVNDANLHSASHQIPPYVPDSHDCFAEDCGGDSSSHQVEFEVVR 539
               ||....|            ....::..:..|.||..|..
Mouse   319 YGISSTAPTP------------ATAGHVWMSKQQAPPPPPQQ----------------------- 348

  Fly   540 PQTVTMTMTCTLPYGGPDAGHTTFQADDFNAIPSAAEDSECSILTTSNSPQIGFNGSSFVEADAI 604
                        |...|.|.....|.......|.|.:..:...|||.:| :.|.:..:.::.:.:
Mouse   349 ------------PPQAPQAPQAPPQQQAPPQQPQAPQQQQAHTLTTLSS-EPGQSQRTHIKTEQL 400

  Fly   605 GSTCTYAQQDYTGSVIE----------------THNDLNYAAHDNNGALLAY 640
            ..:....||.::...|.                |.:..:||.|.|:|:..::
Mouse   401 SPSHYSEQQQHSPQQISYSPFNLPHYSPSYPPITRSQYDYADHQNSGSYYSH 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	39/70 (56%)
Sox9	NP_035578.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		15/94 (16%)
		Sox_N	22..94	CDD:315171	16/105 (15%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P48436	63..103		11/50 (22%)
		PQA. /evidence=ECO:0000250\|UniProtKB:P48436	63..103		11/50 (22%)
		SOX-TCF_HMG-box	104..174	CDD:238684	38/69 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..271		32/183 (17%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P48436	224..307		22/131 (17%)
		9aaTAD 1. /evidence=ECO:0000250\|UniProtKB:P48436	275..284		3/23 (13%)
		9aaTAD 2. /evidence=ECO:0000250\|UniProtKB:P48436	290..298		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..429		18/129 (14%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P48436	392..507		9/61 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838561
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740