DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox14 and Sox8

DIOPT Version :9

Sequence 1:NP_001286801.1 Gene:Sox14 / 37822 FlyBaseID:FBgn0005612 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_035577.1 Gene:Sox8 / 20681 MGIID:98370 Length:464 Species:Mus musculus


Alignment Length:415 Identity:111/415 - (26%)
Similarity:180/415 - (43%) Gaps:91/415 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 VAAAAPKTPKTPE-PRSTHTHTHTHSQHFSPPPRESEMDG---------------ERSPSHSGHE 146
            ::.|..:.|.:|. ..|:.:|.........|.|..||..|               ||.|:.....
Mouse     4 MSEARAQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGGGGRGDTAEAADERFPACIRDA 68

  Fly   147 MTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPD 211
            ::..:.|.|.|||    .:||...     ...|.|..| |:||||||||||:|..|||:.::.|.
Mouse    69 VSQVLKGYDWSLV----PMPVRGG-----GGGTLKAKP-HVKRPMNAFMVWAQAARRKLADQYPH 123

  Fly   212 LHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQKKQT----RS------- 265
            |||||:||.||:.|:|||:.:|:|::.|||:||..|..::|:|||:|:::::    ||       
Mouse   124 LHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKTGRSDSDSGTE 188

  Fly   266 ----PGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTTAGRKSKRSTSTCQSGSASK-RLRN- 324
                ||......||...||.:.:.::     |...:|..|.....|.......:||..: ||.. 
Mouse   189 LGHHPGGPMYKADAVLGEAHHHSDHH-----TGQTHGPPTPPTTPKTDLHQASNGSKQELRLEGR 248

  Fly   325 ---DSG----DTSSKPKYEVKMESAEQLNSADIILPSADNLISYQSSEYLPLSTLSNADCDEKLH 382
               |||    |.|:....|:..|....:::.|:          ::..:||||:.          |
Mouse   249 RLVDSGRQNIDFSNVDISELSSEVISNMDTFDV----------HEFDQYLPLNG----------H 293

  Fly   383 SELSSGPLESRENLSEVVNRFLPLFLGGNEDSQLGVSSLTQSQ--HNQSDPTAGLMDNISDISPI 445
            |.|.:.|.::..:.|          .||...|..|.:.:..|.  .::..|:|..  :.::..|:
Mouse   294 SALPTEPSQATASGS----------YGGASYSHSGATGIGASPVWAHKGAPSASA--SPTEAGPL 346

  Fly   446 NDREELTEEVMRYLPYLEVNPSSDG 470
              |.::..|.:....|.:.:..|.|
Mouse   347 --RPQIKTEQLSPSHYNDQSHGSPG 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox14NP_001286801.1 SOX-TCF_HMG-box 186..257 CDD:238684 40/70 (57%)
Sox8NP_035577.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..55 10/50 (20%)
Sox_N 18..86 CDD:315171 16/71 (23%)
Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P57073 55..97 12/50 (24%)
SOX-TCF_HMG-box 98..168 CDD:238684 39/69 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..244 22/94 (23%)
Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P57073 221..299 21/97 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..315 7/42 (17%)
Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P57073 347..464 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..374 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..464
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838588
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.740

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