DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and Sox10

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_035567.1	Gene:	Sox10 / 20665	MGIID:	98358	Length:	466	Species:	Mus musculus

Alignment Length:	545	Identity:	117/545 - (21%)
Similarity:	192/545 - (35%)	Gaps:	175/545 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 APKADSTPHTLPPFSPSPSPASSP-----------SPAPAQTPGAQKTQSQAAITHPAAVASPSA 96
            :|.....|..|   ||..:|:..|           ||.|.:....:|.|
Mouse    13 SPVGSEEPRCL---SPGSAPSLGPDGGGGGSGLRASPGPGELGKVKKEQ---------------- 58

  Fly    97 PVAAAAPKTPKTPEPRSTHTHTHTHSQHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFG 161
                                             ::.|.|.::.|......::..:.|.|.:||..
Mouse    59 ---------------------------------QDGEADDDKFPVCIREAVSQVLSGYDWTLVPM 90

  Fly   162 SARVPVNSSTPYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQ 226
            ..||        :.|:::|.    |:||||||||||:|..|||:.::.|.|||||:||.||:.|:
Mouse    91 PVRV--------NGASKSKP----HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWR 143

  Fly   227 LLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQKK--------QTRSPGSLKPNQDADGCEAR-- 281
            ||::.||:|:|.|||:||..|..::|:|||:|:::        :...||.......|...:|.
Mouse   144 LLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGGEAEQGGAAAIQAHYK 208

  Fly   282 ------------NDTTNNNNSLTTLAINGTTTAGRKSKRSTSTCQSGSASKRLRNDSGDTSSKPK 334
                        :..::.|....:...:|..|.....|   :..|||.|..:....|.....||.
Mouse   209 SAHLDHRHPEEGSPMSDGNPEHPSGQSHGPPTPPTTPK---TELQSGKADPKRDGRSLGEGGKPH 270

  Fly   335 Y--------EVKMESAEQLNSADI-----ILP---SADNLISYQSSEY----------------- 366
            .        |:..|....:.:.|:     .||   ...::.||.::.|
Mouse   271 IDFGNVDIGEISHEVMSNMETFDVTELDQYLPPNGHPGHVGSYSAAGYGLGSALAVASGHSAWIS 335

  Fly   367 ------LPLSTLSNADCDEKLHSELS--SGPLESRENLSEVVNRFLPLFLGGNEDSQLGVSSLTQ 423
                  ||..:....|...::.:|.:  .||               |.:......||:..:||:.
Mouse   336 KPPGVALPTVSPPGVDAKAQVKTETTGPQGP---------------PHYTDQPSTSQIAYTSLSL 385

  Fly   424 SQHNQSDPTAGLMD-NISDISPINDREELTEEVMRYLPYLEVNPSSDGLTLKVESSSLLGKPLNE 487
            ..:..:.|:..... :.||..|..             ||......:.||   ..:.|.:| |...
Mouse   386 PHYGSAFPSISRPQFDYSDHQPSG-------------PYYGHAGQASGL---YSAFSYMG-PSQR 433

  Fly   488 PVFDS-EDNIVNDANLHSASHQIPP 511
            |::.: .|...:....||.:|...|
Mouse   434 PLYTAISDPSPSGPQSHSPTHWEQP 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	41/70 (59%)
Sox10	NP_035567.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		14/105 (13%)
		Sox_N	12..93	CDD:403592	19/131 (15%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P56693	62..102		10/47 (21%)
		SOX-TCF_HMG-box	103..173	CDD:238684	40/69 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..200		10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..275		11/64 (17%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P56693	228..310		15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..375		5/45 (11%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P56693	353..466		25/138 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..466		6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838594
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740