DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and SYNPO2

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_597734.2	Gene:	SYNPO2 / 171024	HGNCID:	17732	Length:	1261	Species:	Homo sapiens

Alignment Length:	585	Identity:	119/585 - (20%)
Similarity:	186/585 - (31%)	Gaps:	147/585 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QATTEPPLSLRPGTVPTVPATTPARPATITI-----QRRHPAPKADSTPH--------------- 51
            ::||:|..:.:.      |..:| .|..:::     .:|......||.|.
Human   690 RSTTKPMFTFKE------PKVSP-NPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQ 747

  Fly    52 -------TLPPFSPSP-------------SPASSPSPAPAQTPG-AQKTQSQAAITHPAAVASPS 95
                   |.||.:|.|             ||..||..||.|.|. .....|:..:.....:|.||
Human   748 SSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPS 812

  Fly    96 APVA-------AAAP-KTPK--------TPEPR-STHTHTHTHSQHFSPPPRESEMDGERSPSHS 143
            .|.|       .|.| |.|:        ||:|. ||.|..........|......|.|..:...:
Human   813 YPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFA 877

  Fly   144 GHEMTLSMDGIDSSLVFGSARVPVNSSTP-------YSDATRTKK-------HSPGHIKRPMNAF 194
            ..:..:....:||..|...| ....|.||       ||...|...       |||.:   |:.|.
Human   878 KRQSRMEKYVVDSDTVQAHA-ARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSY---PLAAL 938

  Fly   195 MVW------SQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPN 253
            ...      |:|.::|  .:.| |:..::.|.             |||.:.|    .|...:.|:
Human   939 KSQPSAAQPSKMGKKK--GKKP-LNALDVMKH-------------QPYQLNA----SLFTFQPPD 983

  Fly   254 YK-YRPQKKQTRSPGSLK-----PNQDADGCEARNDTTNNNNSLTTLAINGTTTAGRKSKRSTST 312
            .| ..|||...:...:|.     |.:..:.....|...::..|:.......:..|...|..|.|.
Human   984 AKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASP 1048

  Fly   313 CQSG---SASKRLRNDSGDTSSKPKYEVKMESAE-QLNSADIILP--SADNLISYQSSEYLPLST 371
            ...|   |..:...:.|...:.:||:..|..... |.:...:.||  |....||.....|.|..:
Human  1049 VPVGIPTSPKQESASSSYFVAPRPKFSAKKSGVTIQESGRSLSLPGRSVPPPISTSPWVYQPTYS 1113

  Fly   372 LSNADCD--EKLHSELSSGPLESRENLSEVVNRFLP------------------LFLGGNEDSQL 416
            .|:...|  ||.:...:.....::..|..|.:.|.|                  :..|..||...
Human  1114 YSSKPTDGLEKANKRPTPWEAAAKSPLGLVDDAFQPRNIQESIVANVVSAARRKVLPGPPEDWNE 1178

  Fly   417 GVSSLTQSQHNQSDPTAGLMDNISDISPINDREELTEEVMRYLPYLEVNPSS--DGLTLKVESSS 479
            .:|.:.|:|............|::    .|:....|.:....|||.....:|  |...:.:|:.|
Human  1179 RLSYIPQTQKAYMGSCGRQEYNVT----ANNNMSTTSQYGSQLPYAYYRQASRNDSAIMSMETRS 1239

Fly 480 479
Human 1240 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	15/77 (19%)
SYNPO2	NP_597734.2	Interaction with VPS18. /evidence=ECO:0000269\|PubMed:23434281	1..180
		PDZ_signaling	7..85	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..174
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..369
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q91YE8	398..406
		Interaction with ACTN2. /evidence=ECO:0000269\|PubMed:20554076	481..663
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..803		24/119 (20%)
		F-actin binding. /evidence=ECO:0000269\|PubMed:23225103	534..663
		Interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q91YE8	607..811		25/127 (20%)
		Interaction with BAG3. /evidence=ECO:0000269\|PubMed:23434281	615..626
		PPPY motif. /evidence=ECO:0000305\|PubMed:23434281	619..622
		Interaction with ACTN2. /evidence=ECO:0000269\|PubMed:20554076	664..924		52/241 (22%)
		F-actin bundling activity. /evidence=ECO:0000269\|PubMed:23225103	664..916		51/233 (22%)
		F-actin binding. /evidence=ECO:0000269\|PubMed:23225103	664..803		24/119 (20%)
		Actin binding. /evidence=ECO:0000250\|UniProtKB:Q91YE8	751..900		36/149 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..870		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	937..956		4/20 (20%)
		Interaction with ZYX. /evidence=ECO:0000269\|PubMed:16885336	1000..1019		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1041..1064		5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900