Protein Alignment Sox14 and sox10

DIOPT Version :10

• Sequence 1: NP_476894.1
• Gene: Sox14 / 37822
• FlyBaseID: FBgn0005612
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_571950.1
• Gene: sox10 / 140616
• ZFINID: ZDB-GENE-011207-1
• Length: 485
• Species: Danio rerio
• Alignment Length: 632
• Identity: 139/632 - (21%)
• Similarity: 223/632 - (35%)
• Gaps: 222/632 - (35%)

  Fly    43 APKADSTPHTLPPFSPSPSPASSPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAAAPKTPK 107
            :|......|::.|...|.:|..:.||.|.|       |||.     :.:....|.|:.....
Zfish    14 SPGVSDDGHSMSPGHSSGAPGGADSPLPGQ-------QSQM-----SGIGDDGAGVSGGVSV--- 63

  Fly   108 TPEPRSTHTHTHTHSQHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTP 172
                                   :|:.:.:|.|......::..::|.|.:||  ...|.|||.:
Zfish    64 -----------------------KSDEEDDRFPIGIREAVSQVLNGYDWTLV--PMPVRVNSGS- 102

  Fly   173 YSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYI 237
                    |..| |:||||||||||:|..|||:.::.|.|||||:||.||:.|:||::.||:|:|
Zfish   103 --------KSKP-HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNETDKRPFI 158

  Fly   238 IEAEKLRKLHMIEYPNYKYRPQKKQTRSPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTTA 302
            .|||:|||.|..:||.|||:|::::...|||   :.:|| ..:..:.:::.:...:|.:
Zfish   159 EEAERLRKQHKKDYPEYKYQPRRRKNGKPGS---SSEAD-AHSEGEVSHSQSHYKSLHL------ 213

  Fly   303 GRKSKRSTSTCQSGSASKRLRND-----SGDTSS------KPKYEV--------KMESAEQLNSA 348
                    .....|:|...|.:.     :|.:.|      .||.|:        |.|.....:..
Zfish   214 --------EVAHGGAAGSPLGDGHHPHATGQSHSPPTPPTTPKTELQGGKSGEGKREGGASRSGL 270

  Fly   349 DIILPSADNLISYQSSEYLPLSTLSNADCDEKLHSELSS-GPLESRENLSEVVNRFLPLFLGGNE 412
            .:   .||...:..|:...|.....|.|..|..|..::: .|.:..|     .:::||
Zfish   271 GV---GADGSSASSSASGKPHIDFGNVDIGEISHDVMANMEPFDVNE-----FDQYLP------- 320

  Fly   413 DSQLGVSSLTQSQHNQSDPTAGLMDNISDISPINDREELTEEVMRYLPYLEVNPSSDGLTLKVES 477
                      .:.|.|:..||                             ....::...|..: |
Zfish   321 ----------PNGHPQASATA-----------------------------SAGSAAPSYTYGI-S 345

  Fly   478 SSLLGKPLNEPVFDSEDNIVNDANLHSASHQIPPYVPDSHDCFAEDCGGDSSSHQVEFEVVRP-- 540
            |:|..                 |:.||.:......:|..     :..|.|....|::.|...|
Zfish   346 SALAA-----------------ASGHSTAWLSKQQLPSQ-----QHLGADGGKTQIKSETHFPGD 388

  Fly   541 -----QTVTMTMTCTLPYGGPDAGHTTFQADDFNAIPSAAEDSECSILTTSNSPQIGFNGSSFVE 600
                 ..||.| ..|||:..             :|.||.|..::                  |.|
Zfish   389 TAASGSHVTYT-PLTLPHYS-------------SAFPSLASRAQ------------------FAE 421

  Fly   601 ADAIGSTCTYAQQDYTGSVIETHNDLNYAAHDNNGALLAYTFEDLPP 647
                     ||:...:||         |.||.:..:.|...|..:.|
Zfish   422 ---------YAEHQASGS---------YYAHSSQTSGLYSAFSYMGP 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_476894.1	HMG-box_SoxC	186..261	CDD:438838	45/74 (61%)
sox10	NP_571950.1	Sox_N	13..97	CDD:463586	21/122 (17%)
		HMG-box_SoxE	107..181	CDD:438840	45/73 (62%)