DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and Synpo2

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_536699.2	Gene:	Synpo2 / 118449	MGIID:	2153070	Length:	1257	Species:	Mus musculus

Alignment Length:	595	Identity:	125/595 - (21%)
Similarity:	196/595 - (32%)	Gaps:	180/595 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PAPKADSTPHTLPPFSPSPSPASSPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAAAP--- 103
            ||.|:.|:...:.|.||..||..:|:..||.:........|........:|.|:||.|..|.
Mouse   752 PAVKSPSSSQPVAPVSPVWSPGVAPAQRPAFSTSNPPNPPQVTAVSSIKIAQPAAPPARPASALN 816

  Fly   104 -----KTPK--------TPEPRSTHTHTHTHSQHFSPPPRE-SEMDGERSPSHSGHEMTLSMDGI 154
                 |.|:        ||:|.:.....:........|..| ..|.|:.:...:..:..:....:
Mouse   817 LAGPFKGPQAVVVSHNYTPKPSAPTPLVNAAPAGAGGPSNELPGMSGKGAQLFAKRQSRMEKYVV 881

  Fly   155 DSSLVFGSARVPVNSSTP-------YSDATRTKK-------HSPGHIKRPMNAFMVWSQMERRKI 205
            ||..| .:..|...|.||       ||...|...       |||.:   |:.|           |
Mouse   882 DSDTV-QAHTVRAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSY---PLAA-----------I 931

  Fly   206 CERTPDLHNAEISKELGRR-WQLLSKDDKQPYIIEAEKLRKLHMIEYPNYK-YRPQK---KQTRS 265
            ..:.|....::.||:.|:: ...|.....|||.:.|    .|...:.|:.| ..|||   |.:.:
Mouse   932 KSQPPGAQASKTSKKKGKKPLNTLDVMKHQPYQLNA----SLFTFQPPDSKDGLPQKSTVKVSSA 992

  Fly   266 PG---SLKPNQDADGCEARNDTTNNNNSLTTLAINGTTT-----AGRKSKRSTSTCQSGSASKRL 322
            |.   :|.|.|      |...:..|..:.:..::...|:     |...:...:::....|.....
Mouse   993 PAMKQALPPRQ------ANVGSPTNAQASSVYSVPAYTSQPNFFAAEATSPVSASPVPVSVPTSP 1051

  Fly   323 RNDSGDTS----SKPKYEVKMESAE-QLNSADIILP--SADNLIS-----YQSS-EYLPLSTLSN 374
            :.:|..||    .:||:..|..... |.|...:.||  ||..:||     |||: .|....|...
Mouse  1052 KQESTSTSYFVAPRPKFSAKKSGVTVQENGRSLSLPGRSAPPIISASPWLYQSACNYSSKPTFEL 1116

  Fly   375 ADCDEKLHSELSSGPLESRENLSEVVNRFLPLFL------------------GGNEDSQLGVSSL 421
                ||.:...:.....:|..|..|.:.|.|..:                  |..||.:..:|.:
Mouse  1117 ----EKANKRPTPWEAAARSPLGLVDDAFRPRNIQESIVAHVVSAARRKVSPGSQEDWKERLSFV 1177

  Fly   422 TQSQHNQSDPTAGLMDNISDISPINDREELTEEVMRYLPYLEVNPSSDGLTLKVESSSLLGKPLN 486
            .|:|..          |:|    .::|:|.                                |..
Mouse  1178 PQTQKT----------NMS----FSERQEY--------------------------------PAP 1196

  Fly   487 EPVFDSEDNIVNDANLHSASHQI----PPYVPDSHDCFAEDCGGDSSSHQVEFEVVRPQTVTMTM 547
            .||           |.|.:||.:    .|||     |:.::...|..:..:|         |.:.
Mouse  1197 SPV-----------NSHVSSHSLYSSQLPYV-----CYRQESRNDLKTMSME---------TRSE 1236

  Fly   548 TCTLPYGGPD 557
            .| ||.||.|
Mouse  1237 YC-LPLGGYD 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	15/72 (21%)
Synpo2	NP_536699.2	PDZ_signaling	7..85	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..52
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..112
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..272
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..359
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:16309678	388..396
		Interaction with YWHAB. /evidence=ECO:0000269\|PubMed:15883195	551..557
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..817		19/64 (30%)
		Interaction with YWHAB. /evidence=ECO:0000269\|PubMed:15883195	599..804		14/51 (27%)
		PPPY motif. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	611..614
		Interaction with ACTN2. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	656..917		38/165 (23%)
		F-actin bundling activity. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	656..909		37/157 (24%)
		F-actin binding. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	656..796		13/43 (30%)
		Actin binding. /evidence=ECO:0000269\|PubMed:11673475	740..893		32/141 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..863		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..952		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	970..1012		11/47 (23%)
		Interaction with ZYX. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	993..1012		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1037..1060		3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900