DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and SOX30

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_848511.1	Gene:	SOX30 / 11063	HGNCID:	30635	Length:	753	Species:	Homo sapiens

Alignment Length:	755	Identity:	157/755 - (20%)
Similarity:	257/755 - (34%)	Gaps:	226/755 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KPNQATTEPPLSLRPGTVPTVPATTPARPATITI--QRRHPAPKADST--PHTLPPFSPSPS--- 61
            :|:....:||.:....|  :.|...|.:|..:.:  :::...|..|.:  |.......|..|
Human   104 RPDLRLLQPPTASDGAT--SRPELHPVQPLALHVKAKKQKLGPSLDQSVGPRGAVETGPRASRVV 166

  Fly    62 PASSPSPAPAQTPGAQKTQSQA-----------AITHPAAV--------------------ASPS 95
            ....|.||.....|.:|.:.:|           |...|||:                    |.|:
Human   167 KLEGPGPALGYFRGDEKGKLEAEEVMRDSMQGGAGKSPAAIREGVIKTEEPERLLEDCRLGAEPA 231

  Fly    96 -------------APVAAA-APKTPKTPEPRSTHT-HTHTHSQHFSPPPRE-------------S 132
                         ||.:.| .|.......|.:.|| ......|....||.|             :
Human   232 SNGLVHGSAEVILAPTSGAFGPHQQDLRIPLTLHTVPPGARIQFQGAPPSELIRLTKVPLTPVPT 296

  Fly   133 EMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPMNAFMVW 197
            :|.....||     :.:....:..:::...|.:|   .||:|      |...||:||||||||||
Human   297 KMQSLLEPS-----VKIETKDVPLTVLPSDAGIP---DTPFS------KDRNGHVKRPMNAFMVW 347

  Fly   198 SQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQK-K 261
            :::.|..:.:..|..:|||||.:||..|..||::.|:||..||:|:::.|..|:|.:.|:|:. |
Human   348 ARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRPGK 412

  Fly   262 QTRSPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTTAGRKSKRSTSTCQSGSASKRLRNDS 326
            :.|.|.|:.        ...:.||.|     .::.|.||....:|
Human   413 RKRFPLSVS--------NVFSGTTQN-----IISTNPTTVYPYRS-------------------- 444

  Fly   327 GDTSSKPKYEVKMESAEQLNSADIILPSADNLISYQSSE-----YLPLSTLSNADCDEKLHSELS 386
                  |.|.|             ::||..|.|::...|     .||...:.:..........:|
Human   445 ------PTYSV-------------VIPSLQNPITHPVGETSPAIQLPTPAVQSPSPVTLFQPSVS 490

  Fly   387 SGPLESRENLSEVVNRFLP--LFLGGNEDSQLGVSSL-TQSQHNQSDPTAGLMDNISDISPINDR 448
            |....:.::.|..|...||  .|.|   .||.....| :::.|....||...:::.:.||.....
Human   491 SAAQVAVQDPSLPVYPALPPQRFTG---PSQTDTHQLHSEATHTVKQPTPVSLESANRISSSAST 552

  Fly   449 EE---LTEEVMRYLPYLEVNPSSDGLTLKVESSSLLGKPLNEPVFDSEDNIVNDANLHSA----S 506
            ..   .|..:.....|..|:|......:...|      |:..|.......:.:.|.|...    |
Human   553 AHARFATSTIQPPREYSSVSPCPRSAPIPQAS------PIPHPHVYQPPPLGHPATLFGTPPRFS 611

  Fly   507 HQIPPYVPDSHDCFAEDCGGDSSSHQVEFEVVRPQTVTMTMTCTLPYGGPDAGHTTFQADDFNAI 571
            ...|.::|..|...:..|                           ||..|..|:..|
Human   612 FHHPYFLPGPHYFPSSTC---------------------------PYSRPPFGYGNF-------- 641

  Fly   572 PSAAEDSECSILTTSNSPQIGFNGSSFVEADAIGSTCT--YAQQDYTGSVIETHN-----DLN-- 627
            ||:.  .||          :.:....:.:.:.|.||..  |:.:||:.....:.|     ::|
Human   642 PSSM--PEC----------LSYYEDRYPKHEGIFSTLNRDYSFRDYSSECTHSENSRSCENMNGT 694

  Fly   628 --YAAHDNNGALLAYTFEDLPPQPTGSHLEFNTNKYEFAS 665
              |.:|.::|.      |:|.|.|   .|:..|.:..|.:
Human   695 SYYNSHSHSGE------ENLNPVP---QLDIGTLENVFTA 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	32/70 (46%)
SOX30	NP_848511.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..161		3/23 (13%)
		SOX-TCF_HMG-box	336..406	CDD:238684	32/69 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..575		13/63 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..753		157/755 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148487
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740