| Sequence 1: | NP_611863.1 | Gene: | PPP1R15 / 37820 | FlyBaseID: | FBgn0034948 | Length: | 317 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_055145.3 | Gene: | PPP1R15A / 23645 | HGNCID: | 14375 | Length: | 674 | Species: | Homo sapiens |
| Alignment Length: | 433 | Identity: | 94/433 - (21%) |
|---|---|---|---|
| Similarity: | 138/433 - (31%) | Gaps: | 172/433 - (39%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 31 EQYRFGPSRPLSAGSR-TLWK--PNKVHQEAPEVKPLEVPEDLRIPTLQP-----DPLNPLATMM 87
Fly 88 SFKLMAMDVVTQMQTALHK-CVNAQSPPGAK---------------------------MAGIELD 124
Fly 125 ALRRCVPSSCYFFIDLHPHHGF---------------KDTAEDCPTSQASSDRNNNAGCSQGSAA 174
Fly 175 K----SSWQRQ---RSISECSEDSFICFEDDAEQAD--------------------EDVEEDEDD 212
Fly 213 D------DDDSSVQFTACGEDEN-----------------------TEELKACQ-------C--- 238
Fly 239 -----------------------------------SDDSSTPVK--KVRFNMKPEVHVMLAWDYA 266
Fly 267 YRAARKSEWQVMARDRDRFQQRIRRISPILNAVLTPVHRDRVY 309 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| PPP1R15 | NP_611863.1 | PP1c_bdg | <243..309 | CDD:287462 | 29/67 (43%) |
| PPP1R15A | NP_055145.3 | Required for localization in the endoplasmic reticulum | 1..60 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 65..504 | 63/319 (20%) | |||
| 4 X 34 AA approximate repeats | 337..510 | 36/175 (21%) | |||
| Interaction with SMAD7. /evidence=ECO:0000269|PubMed:14718519 | 337..510 | 36/175 (21%) | |||
| Interaction with KMT2A/MLL1 | 483..555 | 9/71 (13%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 534..554 | 4/19 (21%) | |||
| Interaction with SMARCB1 | 536..583 | 15/46 (33%) | |||
| PP1c_bdg | <549..608 | CDD:313670 | 24/58 (41%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 625..674 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165149457 | |
| Domainoid | 1 | 1.000 | 55 | 1.000 | Domainoid score | I11157 |
| eggNOG | 1 | 0.900 | - | - | E1_2DZKW | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 1 | 1.000 | - | - | FOG0006935 | |
| OrthoInspector | 1 | 1.000 | - | - | oto89513 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_113613 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR16489 |
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R5794 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 8 | 7.860 | |||||