DRSC/TRiP Functional Genomics Resources

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Protein Alignment PPP1R15 and PPP1R15A

DIOPT Version :10

Sequence 1:NP_611863.1 Gene:PPP1R15 / 37820 FlyBaseID:FBgn0034948 Length:317 Species:Drosophila melanogaster
Sequence 2:NP_055145.3 Gene:PPP1R15A / 23645 HGNCID:14375 Length:674 Species:Homo sapiens


Alignment Length:433 Identity:94/433 - (21%)
Similarity:138/433 - (31%) Gaps:172/433 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 EQYRFGPSRPLSAGSR-TLWK--PNKVHQEAPEVKPLEVPEDLRIPTLQP-----DPLNPLATMM 87
            |.:|...| .||.||: :.|.  |.:...:|.|.|..|..:..|..::.|     ||       .
Human   202 EAHRTSTS-ALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDP-------R 258

  Fly    88 SFKLMAMDVVTQMQTALHK-CVNAQSPPGAK---------------------------MAGIELD 124
            |::..:.:...:.:...|| ....::.||.:                           :...|.|
Human   259 SWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKD 323

  Fly   125 ALRRCVPSSCYFFIDLHPHHGF---------------KDTAEDCPTSQASSDRNNNAGCSQGSAA 174
            ....|.|  |     :.|...|               :|..||..:...|.:....|..|..:.|
Human   324 GEAECPP--C-----IPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPA 381

  Fly   175 K----SSWQRQ---RSISECSEDSFICFEDDAEQAD--------------------EDVEEDEDD 212
            .    .||..|   .:..|..|||.....:|..:|:                    ||.||:||:
Human   382 TGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDE 446

  Fly   213 D------DDDSSVQFTACGEDEN-----------------------TEELKACQ-------C--- 238
            |      :|||.   .|.||.|:                       |||.:|.:       |   
Human   447 DVDSEDKEDDSE---AALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFR 508

  Fly   239 -----------------------------------SDDSSTPVK--KVRFNMKPEVHVMLAWDYA 266
                                               ..|..||:|  ||||:.|..||.:..|...
Human   509 VAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGP 573

  Fly   267 YRAARKSEWQVMARDRDRFQQRIRRISPILNAVLTPVHRDRVY 309
            .:|||:..|:.:||||.||.:||.:....|:..|||..|.|.:
Human   574 AQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAW 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PPP1R15NP_611863.1 PP1c_bdg <242..312 CDD:431311 29/70 (41%)
PPP1R15ANP_055145.3 Required for localization in the endoplasmic reticulum 1..60
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..504 63/319 (20%)
4 X 34 AA approximate repeats 337..510 36/175 (21%)
Interaction with SMAD7. /evidence=ECO:0000269|PubMed:14718519 337..510 36/175 (21%)
Interaction with KMT2A/MLL1 483..555 9/71 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..554 4/19 (21%)
Interaction with SMARCB1 536..583 15/46 (33%)
PP1c_bdg <549..608 CDD:431311 24/58 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 625..674
Blue background indicates that the domain is not in the aligned region.

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