DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PPP1R15 and Ppp1r15a

DIOPT Version :9

Sequence 1:	NP_611863.1	Gene:	PPP1R15 / 37820	FlyBaseID:	FBgn0034948	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_598230.2	Gene:	Ppp1r15a / 171071	RGDID:	621526	Length:	578	Species:	Rattus norvegicus

Alignment Length:	280	Identity:	64/280 - (22%)
Similarity:	92/280 - (32%)	Gaps:	90/280 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 HKCVNAQSPPGAKMAGIELDALRRCVPSSCYFFIDLHPHHGFKDT--AEDCPTSQASSDRNNNAG 167
            |.|.||::..|.....:       |..|:   |:....:...:||  .||.....|..|..:...
  Rat   259 HPCQNAEAEEGGPETSV-------CSGSA---FLKAWVYRPGEDTEEEEDSDLDSAEEDTAHTCT 313

  Fly   168 CSQGSAAKSSWQRQRSISECSEDSFICFEDDAEQADEDV---------------------EEDED 211
            ....||...:|..:.......||     :.|.:.|:||.                     |:.|:
  Rat   314 TPHTSAFLKAWVYRPGEDTEEED-----DGDWDSAEEDTAQSCTTPHTSAFLKAWVYRPGEDTEE 373

  Fly   212 DDDDDS----------SVQFT----------ACGEDE---------------------------- 228
            :||.::          |.|.|          .|||.|
  Rat   374 EDDSENVAPVDSETVDSCQSTQHCLPVEKTKGCGEAEPPPFQVAFYLPGQKPAPPWAAPKLPLRL 438

  Fly   229 --NTEELKACQCSDDSSTPVK--KVRFNMKPEVHVMLAWDYAYRAARKSEWQVMARDRDRFQQRI 289
              .....||...:.|...|:|  ||.|:.|..||.:..|....:|||:..|:..||||.||.:||
  Rat   439 QKRLRSFKAPARNQDPEIPLKGRKVHFSEKVTVHFLAVWAGPAQAARRGPWEQFARDRSRFARRI 503

  Fly   290 RRISPILNAVLTPVHRDRVY 309
            .:....|...|||..|.|.:
  Rat   504 AQAEEQLGPYLTPAFRARAW 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPP1R15	NP_611863.1	PP1c_bdg	<243..309	CDD:287462	27/67 (40%)
Ppp1r15a	NP_598230.2	Required for localization in the endoplasmic reticulum. /evidence=ECO:0000250	1..165
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..122
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..314		14/64 (22%)
		3 X approximate repeats	279..375		19/103 (18%)
		Interaction with SMAD7. /evidence=ECO:0000250	319..417		19/102 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..353		6/27 (22%)
		Interaction with KMT2A/MLL1. /evidence=ECO:0000250	363..462		16/98 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..393		5/24 (21%)
		Interaction with SMARCB1. /evidence=ECO:0000250	443..490		15/46 (33%)
		PP1c_bdg	<459..526	CDD:287462	26/65 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..578
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343336
Domainoid	1	1.000	51	1.000	Domainoid score	I11340
eggNOG	1	0.900	-	-		E1_2DZKW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006935
OrthoInspector	1	1.000	-	-		oto96636
orthoMCL	1	0.900	-	-		OOG6_113613
Panther	1	1.100	-	-	LDO	PTHR16489
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.830