DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3065 and Klf3

DIOPT Version :10

Sequence 1:NP_611861.1 Gene:CG3065 / 37818 FlyBaseID:FBgn0034946 Length:400 Species:Drosophila melanogaster
Sequence 2:NP_032479.1 Gene:Klf3 / 16599 MGIID:1342773 Length:344 Species:Mus musculus


Alignment Length:312 Identity:82/312 - (26%)
Similarity:107/312 - (34%) Gaps:130/312 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 VIPNTP-------TPQMLTTSTPIEPM--------KPPPA--------FPTMSGANIHEQASDMI 45
            ||.:||       ||:.||....:||:        .||.|        ||:      |.:||..:
Mouse    36 VIYSTPLPDKFFQTPEGLTHGIQVEPVDLTVNKRGSPPAAGGSPSSLKFPS------HRRASPGL 94

  Fly    46 LRASTIFEDVKHD--EANVE--NVP------------HHGVE----------------------- 71
            ...|:.....|:.  ...|:  .||            .||:.                       
Mouse    95 SMPSSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSH 159

  Fly    72 ---------TEPEDDSHYGGNG-----------NSKIRIMPSVKLMATTL--------------- 101
                     :|..|:|:.|...           ..||:|.|.::...|..               
Mouse   160 LQQPLMVSLSEEMDNSNSGMPVPVIESYEKPLLQKKIKIEPGIEPQRTDYYPEEMSPPLMNPVSP 224

  Fly   102 ------------------------ASDPKRK---FVCPYDNCTKSYGKSSHLRSHLTWHTGIKPF 139
                                    :.|.:||   ..|.||.|.|.|.|||||::|...|||.||:
Mouse   225 PQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPY 289

  Fly   140 VCSEPKCGKGFTRSDELNRHLRTHTGEKPFECIQCTKKFSRSDHLTKHLATH 191
            .|:...|...|.|||||.||.|.|||.|||:|..|.:.|||||||..|...|
Mouse   290 KCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRH 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3065NP_611861.1 COG5048 99..>400 CDD:227381 49/135 (36%)
C2H2 Zn finger 111..133 CDD:275368 12/21 (57%)
C2H2 Zn finger 141..163 CDD:275368 11/21 (52%)
C2H2 Zn finger 171..191 CDD:275368 10/19 (53%)
C2H2 Zn finger 348..368 CDD:275368
C2H2 Zn finger 376..396 CDD:275368
Klf3NP_032479.1 Repressor domain 1..74 11/37 (30%)
KLF3_N 49..259 CDD:410554 33/215 (15%)
9aaTAD, inactive. /evidence=ECO:0000250|UniProtKB:P57682 60..68 2/7 (29%)
CTBP-binding motif 61..65 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..111 10/50 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..254 1/18 (6%)
zf-C2H2 259..283 CDD:395048 12/23 (52%)
C2H2 Zn finger 261..283 CDD:275368 12/21 (57%)
C2H2 Zn finger 291..313 CDD:275368 11/21 (52%)
zf-H2C2_2 305..330 CDD:463886 14/24 (58%)
C2H2 Zn finger 321..341 CDD:275368 10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

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