Protein Alignment Alas and SPTLC2

DIOPT Version :9

• Sequence 1: NP_477281.1
• Gene: Alas / 37815
• FlyBaseID: FBgn0020764
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_004854.1
• Gene: SPTLC2 / 9517
• HGNCID: 11278
• Length: 562
• Species: Homo sapiens
• Alignment Length: 444
• Identity: 124/444 - (27%)
• Similarity: 211/444 - (47%)
• Gaps: 51/444 - (11%)

  Fly    95 YERFFNEQIMKKKRDHSYRVFKKV--------NRLAGDGLFPHALEYSERTEKPITVWCSNDYLG 151
            :|.|:...:..:.||:..|....|        .|.:.|  :..:.:|:....|.:....|.:|||
Human   118 FENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHD--YNWSFKYTGNIIKGVINMGSYNYLG 180

  Fly   152 MSAHPG-VKRAVQDALNRHGSGAGGTRNISGNSLHHERLESKLAELHQKEAALLFTSCFVANDST 215
            .:.:.| .:.|....|..:|:|...||...||...||.||..:|.....|||:.:...|..|...
Human   181 FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMN 245

  Fly   216 LFTLAKLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHNDVDHLHQLLK--------QTDKSVP 272
            :..|..  .||.|.||..||||:::|.|.||....||:||::..|.:|||        :|.:...
Human   246 IPALVG--KGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWK 308

  Fly   273 KI-VAFETVHSMTGAICPLEELLDVAHEHGAITFIDEVHAVGLYGDHGAGVGERDGV-LHKMDII 335
            || :..|.::||.|:|..|.|::.:..::.|..::||.|::|..|..|.||.|..|: ...:|::
Human   309 KILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVM 373

  Fly   336 SGTLGKAFGNIGGYIAGTHNLVDMIRSYAAGFIFTTSLPPTVLCGALEAVNILASEEGRQL-RHL 399
            .||..|:||..||||.|...|:|.:|:::...::.|||.|.|:...:.::..:..::|..| :..
Human   374 MGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKEC 438

  Fly   400 HQR---NVSYLKSLLKREGFPV---EETPSHIIPIKIGDPLKSSQISNVLIEQFGHYLQSINYPT 458
            .|:   |..|.:..||..||.:   |::|  ::|:.:..|.|        |..||..:...|...
Human   439 VQQLAENTRYFRRRLKEMGFIIYGNEDSP--VVPLMLYMPAK--------IGAFGREMLKRNIGV 493

  Fly   459 VARG-------QEKLRLAPTPFHTFEMMNALVTDLKKVWEMVDLSTN----VPL 501
            |..|       :.:.|...:..||.|:::..:.::.:|.:::.|..:    |||
Human   494 VVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPL 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alas	NP_477281.1	AAT_I	93..495	CDD:302748	120/432 (28%)
		BioF	95..490	CDD:223234	119/427 (28%)
SPTLC2	NP_004854.1	AAT_I	67..542	CDD:418510	121/437 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810