DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alas and Alas1

DIOPT Version :9

Sequence 1:	NP_477281.1	Gene:	Alas / 37815	FlyBaseID:	FBgn0020764	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_077810.2	Gene:	Alas1 / 65155	RGDID:	68392	Length:	642	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	285/514 - (55%)
Similarity:	354/514 - (68%)	Gaps:	30/514 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QSYGSHCPV----VGKTLVSGEKKLSL-VAASVTRSHSTGANAHANAGGPATANATAPVSAPA-- 80
            ||.||.||.    :.:|..|..:|.|| :...|...|:.......:...|:..||......|:
  Rat   104 QSSGSKCPFLAAQLSQTGSSVFRKASLELQEDVQEMHAVRKEVAQSPVLPSLVNAKRDGEGPSPL 168

  Fly    81 ---------SADPGKAS---------AKETFPYERFFNEQIMKKKRDHSYRVFKKVNRLAGDGLF 127
                     ...|.:.|         :..||.|:.||.::|.:||.||:|||||.|||.|  .:|
  Rat   169 LKNFQDIMRKQRPERVSHLLQDNLPKSVSTFQYDHFFEKKIDEKKNDHTYRVFKTVNRRA--QIF 231

  Fly   128 PHALEYSER--TEKPITVWCSNDYLGMSAHPGVKRAVQDALNRHGSGAGGTRNISGNSLHHERLE 190
            |.|.:|::.  |:|.::|||||||||||.||.|..||.:.:.:||:||||||||||.|..|..||
  Rat   232 PMADDYTDSLITKKQVSVWCSNDYLGMSRHPRVCGAVIETVKQHGAGAGGTRNISGTSKFHVELE 296

  Fly   191 SKLAELHQKEAALLFTSCFVANDSTLFTLAKLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHN 255
            .:||:||.|:|||||:|||||||||||||||::|||||:||:|||||||.|||||.|||:|||||
  Rat   297 QELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHN 361

  Fly   256 DVDHLHQLLKQTDKSVPKIVAFETVHSMTGAICPLEELLDVAHEHGAITFIDEVHAVGLYGDHGA 320
            ||:||.:||:::|.||||||||||||||.||:||||||.|||||.|||||:||||||||||..|.
  Rat   362 DVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGASGG 426

  Fly   321 GVGERDGVLHKMDIISGTLGKAFGNIGGYIAGTHNLVDMIRSYAAGFIFTTSLPPTVLCGALEAV 385
            |:|:||||:.||||||||||||||.:|||||.|..|:|.:|||||||||||||||.:|.||||:|
  Rat   427 GIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLPPMLLAGALESV 491

  Fly   386 NILASEEGRQLRHLHQRNVSYLKSLLKREGFPVEETPSHIIPIKIGDPLKSSQISNVLIEQFGHY 450
            .||.|.|||.||..|||||..::.:|...|.||...||||||:::.|..|:::|.:.|:.:...|
  Rat   492 RILKSNEGRALRRQHQRNVKLMRQMLMDAGLPVIHCPSHIIPVRVADAAKNTEICDELMTRHNIY 556

  Fly   451 LQSINYPTVARGQEKLRLAPTPFHTFEMMNALVTDLKKVWEMVDLSTNVPLSPNACMFC 509
            :|:||||||.||:|.||:||||.||.:|||..:..|...|:.|.|... |.|...|.||
  Rat   557 VQAINYPTVPRGEELLRIAPTPHHTPQMMNFFLEKLLLTWKRVGLELK-PHSSAECNFC 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alas	NP_477281.1	AAT_I	93..495	CDD:302748	259/403 (64%)
Alas	NP_477281.1	BioF	95..490	CDD:223234	256/396 (65%)
Alas1	NP_077810.2	Preseq_ALAS	2..140	CDD:286162	12/35 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..109		3/4 (75%)
		AAT_I	199..604	CDD:302748	260/406 (64%)
		BioF	199..590	CDD:223234	256/392 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	487	1.000	Domainoid score	I370
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1138
OMA	1	1.010	-	-		QHG58214
OrthoDB	1	1.010	-	-		D306770at33208
OrthoFinder	1	1.000	-	-		FOG0000902
OrthoInspector	1	1.000	-	-		otm45357
orthoMCL	1	0.900	-	-		OOG6_100359
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1924
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980