DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alas and alas2

DIOPT Version :9

Sequence 1:	NP_477281.1	Gene:	Alas / 37815	FlyBaseID:	FBgn0020764	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001006926.1	Gene:	alas2 / 448773	XenbaseID:	XB-GENE-487573	Length:	608	Species:	Xenopus tropicalis

Alignment Length:	580	Identity:	294/580 - (50%)
Similarity:	373/580 - (64%)	Gaps:	77/580 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QCPFLNRFTASFIRNYAETLCQSYGSHCPVVGKTLVS---GEKKLSLVAASVTRSHSTGAN---- 59
            :|||..|....|:|.....|.:| ...|||:....:|   |.::.:.....|| ..||||:
Frog     7 RCPFATRDPTVFLRVARPFLLRS-AERCPVMVTCTLSTSPGCEQRTKDTTPVT-GVSTGASNRRT 69

  Fly    60 -AHANAGGPATANATAP------------------------VSA--------------------- 78
             |.| |...|.:|||.|                        :||
Frog    70 LAQA-APQAAISNATCPFIENEIGKSEGIIVQRAGPQVQEDISAFKTDALSSLLIEVQSSLKKKF 133

  Fly    79 ---PASADPG-------------KASAKETFPYERFFNEQIMKKKRDHSYRVFKKVNRLAGDGLF 127
               |...:.|             ..:.:..|.|:.||:.:|.:||.||:||:||.|||.|  ..:
Frog   134 LAPPKKVNLGTGAPLIPTHLIKENMTGRAAFGYDDFFSRRIEEKKSDHTYRLFKTVNRRA--DAY 196

  Fly   128 PHALEYSE--RTEKPITVWCSNDYLGMSAHPGVKRAVQDALNRHGSGAGGTRNISGNSLHHERLE 190
            |.|.:||:  ..:|.::|||||||||||.||.|.:|:.:||..||:||||||||||.|.:|..||
Frog   197 PFAEDYSDLHGEKKEVSVWCSNDYLGMSRHPKVLKAIAEALEEHGAGAGGTRNISGTSKYHVDLE 261

  Fly   191 SKLAELHQKEAALLFTSCFVANDSTLFTLAKLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHN 255
            .:||:||.|:|||||:|||||||||||||||:||||||:||||||||||.|||||||.|.:||||
Frog   262 CELADLHNKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRNSGVTKFVFRHN 326

  Fly   256 DVDHLHQLLKQTDKSVPKIVAFETVHSMTGAICPLEELLDVAHEHGAITFIDEVHAVGLYGDHGA 320
            |..||.:||::.:...||||||||||||.||||||||:.|:||::||:||:||||||||||.|||
Frog   327 DPAHLEELLQKANPKTPKIVAFETVHSMDGAICPLEEVCDIAHKYGALTFVDEVHAVGLYGTHGA 391

  Fly   321 GVGERDGVLHKMDIISGTLGKAFGNIGGYIAGTHNLVDMIRSYAAGFIFTTSLPPTVLCGALEAV 385
            ||||||.|:|||||||||||||||.:|||:|.|.:|:|.:|||||||||||||||.||.||:|:|
Frog   392 GVGERDSVMHKMDIISGTLGKAFGCVGGYVASTASLIDTVRSYAAGFIFTTSLPPMVLAGAVESV 456

  Fly   386 NILASEEGRQLRHLHQRNVSYLKSLLKREGFPVEETPSHIIPIKIGDPLKSSQISNVLIEQFGHY 450
            .:|.||||:.||..|||||.:::.||...|.||...|||||||::|:...:::|.:||:.|:..|
Frog   457 RVLKSEEGQALRRAHQRNVKHMRQLLMDAGLPVINCPSHIIPIRVGNAAINTRICDVLLSQYNIY 521

  Fly   451 LQSINYPTVARGQEKLRLAPTPFHTFEMMNALVTDLKKVWEMVDLSTNVPLSPNACMFCN 510
            :|:||||||.||:|.|||||:|.||.:|||..|..|...|:.|.:..:.| |...|.||:
Frog   522 VQAINYPTVPRGEELLRLAPSPHHTPDMMNYFVESLVSAWKEVGMPLHTP-SAAECNFCH 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alas	NP_477281.1	AAT_I	93..495	CDD:302748	258/403 (64%)
Alas	NP_477281.1	BioF	95..490	CDD:223234	255/396 (64%)
alas2	NP_001006926.1	Preseq_ALAS	2..114	CDD:370250	29/109 (27%)
alas2	NP_001006926.1	AAT_I	164..568	CDD:388495	258/405 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	491	1.000	Domainoid score	I376
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H17
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1052
OMA	1	1.010	-	-		QHG58214
OrthoDB	1	1.010	-	-		D306770at33208
OrthoFinder	1	1.000	-	-		FOG0000902
OrthoInspector	1	1.000	-	-		otm48434
Panther	1	1.100	-	-	O	PTHR13693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R554
SonicParanoid	1	1.000	-	-		X1924
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110