Protein Alignment Alas and alas2

DIOPT Version :10

• Sequence 1: NP_477281.1
• Gene: Alas / 37815
• FlyBaseID: FBgn0020764
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001006926.1
• Gene: alas2 / 448773
• XenbaseID: XB-GENE-487573
• Length: 608
• Species: Xenopus tropicalis
• Alignment Length: 580
• Identity: 294/580 - (50%)
• Similarity: 373/580 - (64%)
• Gaps: 77/580 - (13%)

  Fly     2 QCPFLNRFTASFIRNYAETLCQSYGSHCPVVGKTLVS---GEKKLSLVAASVTRSHSTGAN---- 59
            :|||..|....|:|.....|.:| ...|||:....:|   |.::.:.....|| ..||||:
 Frog     7 RCPFATRDPTVFLRVARPFLLRS-AERCPVMVTCTLSTSPGCEQRTKDTTPVT-GVSTGASNRRT 69

  Fly    60 -AHANAGGPATANATAP------------------------VSA--------------------- 78
             |.| |...|.:|||.|                        :||
 Frog    70 LAQA-APQAAISNATCPFIENEIGKSEGIIVQRAGPQVQEDISAFKTDALSSLLIEVQSSLKKKF 133

  Fly    79 ---PASADPG-------------KASAKETFPYERFFNEQIMKKKRDHSYRVFKKVNRLAGDGLF 127
               |...:.|             ..:.:..|.|:.||:.:|.:||.||:||:||.|||.|  ..:
 Frog   134 LAPPKKVNLGTGAPLIPTHLIKENMTGRAAFGYDDFFSRRIEEKKSDHTYRLFKTVNRRA--DAY 196

  Fly   128 PHALEYSE--RTEKPITVWCSNDYLGMSAHPGVKRAVQDALNRHGSGAGGTRNISGNSLHHERLE 190
            |.|.:||:  ..:|.::|||||||||||.||.|.:|:.:||..||:||||||||||.|.:|..||
 Frog   197 PFAEDYSDLHGEKKEVSVWCSNDYLGMSRHPKVLKAIAEALEEHGAGAGGTRNISGTSKYHVDLE 261

  Fly   191 SKLAELHQKEAALLFTSCFVANDSTLFTLAKLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHN 255
            .:||:||.|:|||||:|||||||||||||||:||||||:||||||||||.|||||||.|.:||||
 Frog   262 CELADLHNKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRNSGVTKFVFRHN 326

  Fly   256 DVDHLHQLLKQTDKSVPKIVAFETVHSMTGAICPLEELLDVAHEHGAITFIDEVHAVGLYGDHGA 320
            |..||.:||::.:...||||||||||||.||||||||:.|:||::||:||:||||||||||.|||
 Frog   327 DPAHLEELLQKANPKTPKIVAFETVHSMDGAICPLEEVCDIAHKYGALTFVDEVHAVGLYGTHGA 391

  Fly   321 GVGERDGVLHKMDIISGTLGKAFGNIGGYIAGTHNLVDMIRSYAAGFIFTTSLPPTVLCGALEAV 385
            ||||||.|:|||||||||||||||.:|||:|.|.:|:|.:|||||||||||||||.||.||:|:|
 Frog   392 GVGERDSVMHKMDIISGTLGKAFGCVGGYVASTASLIDTVRSYAAGFIFTTSLPPMVLAGAVESV 456

  Fly   386 NILASEEGRQLRHLHQRNVSYLKSLLKREGFPVEETPSHIIPIKIGDPLKSSQISNVLIEQFGHY 450
            .:|.||||:.||..|||||.:::.||...|.||...|||||||::|:...:::|.:||:.|:..|
 Frog   457 RVLKSEEGQALRRAHQRNVKHMRQLLMDAGLPVINCPSHIIPIRVGNAAINTRICDVLLSQYNIY 521

  Fly   451 LQSINYPTVARGQEKLRLAPTPFHTFEMMNALVTDLKKVWEMVDLSTNVPLSPNACMFCN 510
            :|:||||||.||:|.|||||:|.||.:|||..|..|...|:.|.:..:.| |...|.||:
 Frog   522 VQAINYPTVPRGEELLRLAPSPHHTPDMMNYFVESLVSAWKEVGMPLHTP-SAAECNFCH 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alas	NP_477281.1	AAT_I	93..495	CDD:450240	258/403 (64%)
alas2	NP_001006926.1	Preseq_ALAS	2..114	CDD:462658	29/109 (27%)
		AAT_I	164..568	CDD:450240	258/405 (64%)