DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alas and Alas2

DIOPT Version :9

Sequence 1:	NP_477281.1	Gene:	Alas / 37815	FlyBaseID:	FBgn0020764	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_038955432.1	Gene:	Alas2 / 25748	RGDID:	2084	Length:	593	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	288/570 - (50%)
Similarity:	359/570 - (62%)	Gaps:	79/570 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CPFLNRFTASFIRNYAETLCQSYG---------------------------------SHCPVVGK 34
            ||.|::.....:...|:|....:|                                 ||||.:..
  Rat    11 CPVLSKGPTGLLGKVAKTYQFLFGIGRCPILATQGPTCSQIHLKATKAGADSPSWTKSHCPFMLS 75

  Fly    35 TLVSGEKKLSLVAA-------------------------SVTRSHSTGANAHANAGGPATANATA 74
            .|...:.|:...||                         |.|||.|.          |...:...
  Rat    76 ELQDRKSKIVQRAAPEVQEDVKTFKTVPYFLSDLLSFMESTTRSQSV----------PRFQDPEQ 130

  Fly    75 PVSAPASADPGKASAKETFPYERFFNEQIMKKKRDHSYRVFKKVNRLAGDGLFPHALEYSERT-- 137
            ....|........:..:.|.|::||.::||:||:||:|||||.|||.|  ..:|.|..:||.:
  Rat   131 TGGVPPLLIQNNMTGSQAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWA--NAYPFAQHFSEASMD 193

  Fly   138 EKPITVWCSNDYLGMSAHPGVKRAVQDALNRHGSGAGGTRNISGNSLHHERLESKLAELHQKEAA 202
            .|.::|||||||||:|.||.|.:|:::.|..||:||||||||||.|..|..||.:|||||.|::|
  Rat   194 SKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAELHHKDSA 258

  Fly   203 LLFTSCFVANDSTLFTLAKLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHNDVDHLHQLLKQT 267
            |||:||||||||||||||||||||||:||||||||||.||||||..|.:|||||..||.:||:::
  Rat   259 LLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAVKFVFRHNDPGHLKKLLEKS 323

  Fly   268 DKSVPKIVAFETVHSMTGAICPLEELLDVAHEHGAITFIDEVHAVGLYGDHGAGVGERDGVLHKM 332
            |...||||||||||||.|||||||||.||||::||:||:||||||||||..|||:|||||::||:
  Rat   324 DPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLYGTRGAGIGERDGIMHKL 388

  Fly   333 DIISGTLGKAFGNIGGYIAGTHNLVDMIRSYAAGFIFTTSLPPTVLCGALEAVNILASEEGRQLR 397
            ||||||||||||.:|||||.|.:||||:|||||||||||||||.||.||||:|.:|..|||:.||
  Rat   389 DIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALR 453

  Fly   398 HLHQRNVSYLKSLLKREGFPVEETPSHIIPIKIGDPLKSSQISNVLIEQFGHYLQSINYPTVARG 462
            ..|||||.:::.||...||||...|||||||::|:...:|:|.::|:.:...|:|:||||||.||
  Rat   454 RAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNSKICDLLLAKHSIYVQAINYPTVPRG 518

  Fly   463 QEKLRLAPTPFHTFEMMNALVTDLKKVWEMVDLSTNVPL---SPNACMFC 509
            :|.|||||:|.|:.:||...|..|...|..|.|    ||   |..||.||
  Rat   519 EELLRLAPSPHHSPQMMENFVEKLLLAWTEVGL----PLQDVSVAACNFC 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alas	NP_477281.1	AAT_I	93..495	CDD:302748	259/403 (64%)
Alas	NP_477281.1	BioF	95..490	CDD:223234	256/396 (65%)
Alas2	XP_038955432.1	Preseq_ALAS	5..100	CDD:401101	14/88 (16%)
Alas2	XP_038955432.1	5aminolev_synth	149..554	CDD:273820	261/410 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	487	1.000	Domainoid score	I370
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H17
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1138
OMA	1	1.010	-	-		QHG58214
OrthoDB	1	1.010	-	-		D306770at33208
OrthoFinder	1	1.000	-	-		FOG0000902
OrthoInspector	1	1.000	-	-		otm45357
orthoMCL	1	0.900	-	-		OOG6_100359
Panther	1	1.100	-	-	O	PTHR13693
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1924
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980