Protein Alignment Alas and ALAS1

DIOPT Version :9

• Sequence 1: NP_477281.1
• Gene: Alas / 37815
• FlyBaseID: FBgn0020764
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001291373.1
• Gene: ALAS1 / 211
• HGNCID: 396
• Length: 657
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 297/620 - (47%)
• Similarity: 369/620 - (59%)
• Gaps: 126/620 - (20%)

  Fly     2 QCPFLNRFTASFIRNYAETLCQSYGSHCPVVGKTLVSGEKKLSLVAASVTRSHSTGA-------- 58
            :||||:|...:|::...::|. .|..:||          |.:.:.|....|:.||.|
Human    24 RCPFLSRVPQAFLQKAGKSLL-FYAQNCP----------KMMEVGAKPAPRALSTAAVHYQQIKE 77

  Fly    59 --------------------NAHANAGG---------PATANATAPVS----------------- 77
                                .:..:..|         |||:..||...
Human    78 TPPASEKDKTAKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCK 142

  Fly    78 -------------------APASADPGKASAK--------------------------------- 90
                               |..||.|...|.|
Human   143 ASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPERVSHLLQDNL 207

  Fly    91 ----ETFPYERFFNEQIMKKKRDHSYRVFKKVNRLAGDGLFPHALEYSER--TEKPITVWCSNDY 149
                .||.|:|||.::|.:||.||:|||||.|||.|  .:||.|.:||:.  |:|.::|||||||
Human   208 PKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRA--HIFPMADDYSDSLITKKQVSVWCSNDY 270

  Fly   150 LGMSAHPGVKRAVQDALNRHGSGAGGTRNISGNSLHHERLESKLAELHQKEAALLFTSCFVANDS 214
            ||||.||.|..||.|.|.:||:||||||||||.|..|..||.:||:||.|:|||||:||||||||
Human   271 LGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDS 335

  Fly   215 TLFTLAKLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHNDVDHLHQLLKQTDKSVPKIVAFET 279
            |||||||::|||||:||:|||||||.|||||.|||:|||||||.||.:||:::|.||||||||||
Human   336 TLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFET 400

  Fly   280 VHSMTGAICPLEELLDVAHEHGAITFIDEVHAVGLYGDHGAGVGERDGVLHKMDIISGTLGKAFG 344
            ||||.||:||||||.|||||.|||||:||||||||||..|.|:|:||||:.||||||||||||||
Human   401 VHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFG 465

  Fly   345 NIGGYIAGTHNLVDMIRSYAAGFIFTTSLPPTVLCGALEAVNILASEEGRQLRHLHQRNVSYLKS 409
            .:|||||.|.:|:|.:|||||||||||||||.:|.||||:|.||.|.|||.||..|||||..::.
Human   466 CVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRVLRRQHQRNVKLMRQ 530

  Fly   410 LLKREGFPVEETPSHIIPIKIGDPLKSSQISNVLIEQFGHYLQSINYPTVARGQEKLRLAPTPFH 474
            :|...|.||...||||||:::.|..|::::.:.|:.:...|:|:||||||.||:|.||:||||.|
Human   531 MLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHH 595

  Fly   475 TFEMMNALVTDLKKVWEMVDLSTNVPLSPNACMFC 509
            |.:|||..:.:|...|:.|.|... |.|...|.||
Human   596 TPQMMNYFLENLLVTWKQVGLELK-PHSSAECNFC 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alas	NP_477281.1	AAT_I	93..495	CDD:302748	262/403 (65%)
		BioF	95..490	CDD:223234	259/396 (65%)
ALAS1	NP_001291373.1	Preseq_ALAS	19..154	CDD:286162	22/140 (16%)
		AAT_I	214..619	CDD:302748	263/406 (65%)
		BioF	214..605	CDD:223234	259/392 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	492	1.000	Domainoid score	I367
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1167
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58214
OrthoDB	1	1.010	-	-		D306770at33208
OrthoFinder	1	1.000	-	-		FOG0000902
OrthoInspector	1	1.000	-	-		otm41221
orthoMCL	1	0.900	-	-		OOG6_100359
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R554
SonicParanoid	1	1.000	-	-		X1924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.970