Protein Alignment Alas and Alas1

DIOPT Version :9

• Sequence 1: NP_477281.1
• Gene: Alas / 37815
• FlyBaseID: FBgn0020764
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001278764.1
• Gene: Alas1 / 11655
• MGIID: 87989
• Length: 642
• Species: Mus musculus
• Alignment Length: 614
• Identity: 299/614 - (48%)
• Similarity: 370/614 - (60%)
• Gaps: 112/614 - (18%)

  Fly     2 QCPFLNRFTASFIRN-------YAE---------------TLCQSYGSHCPVVGKTLVSGEKKLS 44
            :||||:|...:|::.       ||:               ||..| ..||..|.:|..:.||:.:
Mouse     7 RCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRTLSTS-AVHCQQVKETPPANEKEKT 70

  Fly    45 LVAA-------SVTRSHSTGANAHANAGGPATAN------------------------------- 71
            ..||       |.......|....:....|||:.
Mouse    71 AKAAVQQAPDESQMAQTPDGTQLPSGHPSPATSQGSGSKCPFLAAQLSQTGSSVFRKASLELQED 135

  Fly    72 -----------ATAPVSAPAS--------ADPGK-------------------------ASAKET 92
                       |.:||  |.|        .||.:                         ..:..|
Mouse   136 VQEMHAVRKEAAQSPV--PPSLVNVKTDGEDPSRLLKNFQDIMRKQRPERVSHLLQDNLPKSVST 198

  Fly    93 FPYERFFNEQIMKKKRDHSYRVFKKVNRLAGDGLFPHALEYSER--TEKPITVWCSNDYLGMSAH 155
            |.|:.||.::|.:||.||:|||||.|||.|  .:||.|.:|::.  |:|.::|||||||||||.|
Mouse   199 FQYDHFFEKKIDEKKNDHTYRVFKTVNRRA--QIFPMADDYTDSLITKKQVSVWCSNDYLGMSRH 261

  Fly   156 PGVKRAVQDALNRHGSGAGGTRNISGNSLHHERLESKLAELHQKEAALLFTSCFVANDSTLFTLA 220
            |.|..||.:.:.:||:||||||||||.|..|..||..||:||.|:|||||:||||||||||||||
Mouse   262 PRVCGAVMETVKQHGAGAGGTRNISGTSKFHVELEQALADLHGKDAALLFSSCFVANDSTLFTLA 326

  Fly   221 KLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHNDVDHLHQLLKQTDKSVPKIVAFETVHSMTG 285
            |::|||||:||:|||||||.|||||.|||:|||||||:||.:||:::|.||||||||||||||.|
Mouse   327 KMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVNHLRELLQRSDPSVPKIVAFETVHSMDG 391

  Fly   286 AICPLEELLDVAHEHGAITFIDEVHAVGLYGDHGAGVGERDGVLHKMDIISGTLGKAFGNIGGYI 350
            |:||||||.|||||.|||||:||||||||||..|.|:|:||||:.||||||||||||||.:||||
Mouse   392 AVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYI 456

  Fly   351 AGTHNLVDMIRSYAAGFIFTTSLPPTVLCGALEAVNILASEEGRQLRHLHQRNVSYLKSLLKREG 415
            |.|..|:|.:|||||||||||||||.:|.||||:|.||.|.|||.||..|||||..|:.:|...|
Mouse   457 ASTSLLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSSEGRALRRQHQRNVKLLRQMLMDAG 521

  Fly   416 FPVEETPSHIIPIKIGDPLKSSQISNVLIEQFGHYLQSINYPTVARGQEKLRLAPTPFHTFEMMN 480
            .||...||||||:::.|..|:::|.:.|:.:...|:|:||||||.||:|.||:||||.||.:|||
Mouse   522 LPVIHCPSHIIPVRVADAAKNTEICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMN 586

  Fly   481 ALVTDLKKVWEMVDLSTNVPLSPNACMFC 509
            ..|..|...|:.|.|... |.|...|.||
Mouse   587 FFVEKLLVTWKRVGLELK-PHSSAECNFC 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alas	NP_477281.1	AAT_I	93..495	CDD:302748	261/403 (65%)
		BioF	95..490	CDD:223234	258/396 (65%)
Alas1	NP_001278764.1	Preseq_ALAS	2..140	CDD:286162	24/133 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..109		14/59 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..163		5/20 (25%)
		AAT_I	199..604	CDD:302748	262/406 (65%)
		BioF	199..600	CDD:223234	260/402 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	489	1.000	Domainoid score	I377
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	543	1.000	Inparanoid score	I1151
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58214
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000902
OrthoInspector	1	1.000	-	-		otm43285
orthoMCL	1	0.900	-	-		OOG6_100359
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R554
SonicParanoid	1	1.000	-	-		X1924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860