DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and Fmo3

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_445885.2	Gene:	Fmo3 / 84493	RGDID:	619761	Length:	531	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	133/462 - (28%)
Similarity:	202/462 - (43%)	Gaps:	107/462 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPK 68
            |.:||||.:||...|..:..|.|.|.||.||.:||.|.:::.|.     :..:|:|:::.||..|
  Rat     5 VAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHTE-----EGRASIYQSVFTNSSK 64

  Fly    69 EVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRV-----LQRKTKWQVLF 128
            |:|.||||....:..:::.:.::.:::..:|...:|.|:|:|::.|.|:     .....||:|..
  Rat    65 EMMCFPDFPYPDDFPNFMHNSKLQEYITSFATEKNLLKYIQFETLVTRINKCPDFSTTGKWEVTT 129

  Fly   129 KDLVTNKIEFQYFDKVLVANGHY---HTPNYSQIPNMERFKGQFLHSHDFRSREVFEGKSVLVIG 190
            :.  .:|.|...||.|::.:||:   |.|..| .|.:.||||:..||.|::....::||.|||||
  Rat   130 EK--NSKKETAVFDAVMICSGHHVYPHLPKDS-FPGLNRFKGKCFHSRDYKEPGTWKGKRVLVIG 191

  Fly   191 AGPSGMDLSNIISRTADRVTISH-----------------------------------------H 214
            .|.||.|::..:|..|.:|.||.                                         :
  Rat   192 LGNSGCDIAAELSHVAQQVIISSRSGSWVMSRVWNDGYPWDMVVITRFQTFLKNNLPTAISDWWY 256

  Fly   215 LTDIGQHSFFEN----------------------------VQQKPDVRELDEKGAFFVDGS-YQE 250
            :..:......||                            |..||:|:|..|..|.|.||: ::.
  Rat   257 MKQMNARFKHENYGLMPLNGTLRKEPVFNDELPARILCGTVSIKPNVKEFTETSAVFEDGTVFEG 321

  Fly   251 FDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGLPFYVCAA-QMMDI 312
            .|.|.|.|||.||:|||  |..|....|....|||...  .:..|:||:|||...:.|| ...|:
  Rat   322 IDCVIFATGYGYAYPFL--DDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTTDL 384

  Fly   313 QARFIMSYYNGSNELPSTEDMLKDTRDRMGK--LWAEGLRKRHAHMLGPK---QIDYFTDLSQTA 372
            |||:......|:..|||..||:.|..::|||  .|           .|..   |.||...:.:.|
  Rat   385 QARWAAQVIRGTCILPSVNDMMDDIDEKMGKKLKW-----------FGNSTTIQTDYIVYMDELA 438

  Fly   373 GVKNIKP 379
            .....||
  Rat   439 SFIGAKP 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	67/199 (34%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	12/25 (48%)
Fmo3	NP_445885.2	FMO-like	2..530	CDD:395602	133/462 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3468
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm9017
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.780