DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fmo-1 and Fmo9

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001102936.1	Gene:	Fmo9 / 685365	RGDID:	1595083	Length:	543	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	131/460 - (28%)
Similarity:	209/460 - (45%)	Gaps:	107/460 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGL----CCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRT 64
            :.:||||.:||    ||    :....|.|.||.||.|||.|.:.:     |..:...|:||::..
  Rat     6 IAVIGAGISGLGAIKCC----LDEDLEPTCFERSDDIGGLWKFQK-----NPSEKMPSIYKSVTI 61

  Fly    65 NLPKEVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQR-----KTKW 124
            |..||:|.|.||.|..:..:|:.:.::.|:...||.||.|..||:|.:.|..|.:|     :.:|
  Rat    62 NTSKEMMCFSDFPIPDHFPNYMHNCKLMDYFRMYAEHFGLLDHIRFKTTVRSVRKRPDFSVQGQW 126

  Fly   125 QVLFKDLVTNKIEFQYFDKVLVANGHYHTPN--YSQIPNMERFKGQFLHSHDFRSREVFEGKSVL 187
            .|:.:  ...|.|...||.:||.:||:..|:  ....|.:|:|:|.:.||.:::|.|.:.||.::
  Rat   127 DVIVE--ADGKQESLVFDGILVCSGHHTDPHLPLKSFPGIEKFEGCYFHSREYKSPEDYVGKRII 189

  Fly   188 VIGAGPSGMDLSNIISRTADRV------------------------------------------- 209
            |:|.|.||:|::..:.|.|.:|
  Rat   190 VVGIGNSGVDIAVELGRVAKQVFLSTRRGSWILHRVWNNGYPMDSSFFTRFNSFLQKLLSTEAVN 254

  Fly   210 -----------------------TISHHLT---DIGQHSFFENVQQKPDVRELDEKGAFFVDGSY 248
                                   .:|.|.|   |:..|.....||.||:|:|.......|.||:.
  Rat   255 KYLEKMMNSRFNHAHYGLQPQHRPLSQHPTVSDDLPNHIISGKVQVKPNVKEFRGTDVVFDDGTV 319

  Fly   249 QE-FDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGL--PFYVCAAQ 308
            :| .|.|.|.|||.::||||  :..|.|.||.| .|||...  ::..|::|:|||  |..: ...
  Rat   320 EEKIDVVIFATGYSFSFPFL--EDLIAVTDNEV-SLYKLMFPPDLEKPTLAVIGLIQPLGI-VLP 380

  Fly   309 MMDIQARFIMSYYNGSNELPSTEDMLKDTRDR---MGKLWAEGLRKRHAHMLGPKQIDYFTDLSQ 370
            :.::|:|:.:..:.|.::|||.:.|..|...|   |.|.:.:.:|    |.:....|:|..:::.
  Rat   381 ISELQSRWAVRVFKGLSKLPSVKIMNADMAQRKKAMAKRYVKTVR----HTIQVDHIEYMDEIAA 441

  Fly   371 TAGVK 375
            .||||
  Rat   442 LAGVK 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	69/202 (34%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	9/91 (10%)
Fmo9	NP_001102936.1	FMO-like	3..532	CDD:109787	131/460 (28%)
		NAD_binding_8	8..>42	CDD:290186	17/37 (46%)
		NADB_Rossmann	<90..>342	CDD:304358	67/255 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3468
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm9017
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.780