DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and LOC685351

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_008767943.1	Gene:	LOC685351 / 685351	RGDID:	1595097	Length:	538	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	137/484 - (28%)
Similarity:	204/484 - (42%)	Gaps:	128/484 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGL----CCARHSIANGFETTVFELSDRIGGTWVYNEATGAVN-GIDVHSSMYKNLR 63
            |.:||||.:||    ||    :..|.|.|.||....|||.|.|.|.:.:.| ||      ||:|.
  Rat     6 VAVIGAGVSGLGAIKCC----LDEGLEPTCFEKRSDIGGLWKYEEISKSGNLGI------YKSLT 60

  Fly    64 TNLPKEVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQR-----KTK 123
            .|..||:..|.|:.|..:..:|:.:.::.::|..||.||.|.|||:|.:.|..:.:|     ..:
  Rat    61 CNTSKEMTAFSDYPIPDHYPNYMHNSKMMEYLRMYARHFGLLKHIQFQTKVCSIKKRPDFSSSGQ 125

  Fly   124 WQVLFKDLVTNKIEFQYFDKVLVANGHY---HTPNYSQIPNMERFKGQFLHSHDFRSREVFEGKS 185
            |.|:.:...|.|.  ..||.::|.:|||   |.| ......:.:|:|..|||.:::....|.||.
  Rat   126 WDVVVETGETQKT--YIFDGIMVCSGHYTEKHFP-LQDFEGISKFQGSCLHSWEYKHPNSFSGKR 187

  Fly   186 VLVIGAGPSGMDLSNIISRTADRVTIS-------------------------------------- 212
            |:|||.|.||.|::..|||.||:|.:|
  Rat   188 VVVIGIGNSGADVAGEISRVADQVFLSTRRGAWVWSRVWDHGNPMDASLFTRYNRAVQKFCPRYL 252

  Fly   213 ---------------------------HHLT----DIGQHSFFENVQQKPDVRELDEKGAFFVDG 246
                                       .|.|    |:..|.....|:.|.:|:......|.|.||
  Rat   253 INRQMEKKLNARFNHANFGLLPQHRILDHRTVFSDDLPSHIITGKVKIKTNVKTFTSTSAVFEDG 317

  Fly   247 SYQEFDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCINIRNPSMALIGLPFYVCAAQMM- 310
            :.:..|.|.|.||||.|||||:.|||| ::..|....|.....:..|::|.||:   |..|..:
  Rat   318 TEENIDVVIFATGYKLAFPFLSDDSGI-LDSQYSMFKYVFPPELEKPTLAFIGI---VQPAGAII 378

  Fly   311 ---DIQARFIMSYYNGSNELPSTEDMLKDTRDRMGKLWAEGLRKRHAHMLGPKQ----------I 362
               ::|:|:::..:.|..:||..:.|:.|.           .||..|.....|.          |
  Rat   379 PTSELQSRWVVRVFTGLQKLPPKKAMMADI-----------YRKHQADKDAIKNLKDSSRRVQFI 432

  Fly   363 DYFTDLSQTAGVK-NIKPVM---TKLHNE 387
            ||..:::...||| |:..::   |||..|
  Rat   433 DYMDEIASEIGVKPNLLSLLLWDTKLAKE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	71/204 (35%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	14/25 (56%)
LOC685351	XP_008767943.1	FMO-like	4..531	CDD:109787	137/484 (28%)
LOC685351	XP_008767943.1	NADB_Rossmann	7..221	CDD:304358	79/226 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345716
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3468
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm9017
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.710