DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and si:dkey-239i20.2

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001038294.1	Gene:	si:dkey-239i20.2 / 557525	ZFINID:	ZDB-GENE-041001-98	Length:	562	Species:	Danio rerio

Alignment Length:	468	Identity:	133/468 - (28%)
Similarity:	210/468 - (44%)	Gaps:	106/468 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPK 68
            |.|||.||:||.|.:..:..|.|...||.||.|||.|.:.|..    .:| .:|:|.:|..|..|
Zfish     5 VAIIGGGTSGLACIKCCLDEGLEPVCFETSDDIGGLWRFKENP----DLD-QASIYHSLIINTSK 64

  Fly    69 EVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQR-----KTKWQV-- 126
            |:|.:.|:.|.|:..:|:.:..|.::...||.:|.||:||:|.:.|:.|..|     ..:|.|
Zfish    65 EMMCYSDYPIPAHFPNYMHNSLIMEYFRMYAENFQLKRHIRFQTRVLHVTPRPDFPHSGQWDVET 129

  Fly   127 LFKDLVTNKIEFQYFDKVLVANGHY---HTPNYSQIPNMERFKGQFLHSHDFRSREVFEGKSVLV 188
            ..||.:..|   |.||.|:|..||:   |.| ....|.::.|||:|.||.|:::.|.:.||..:|
Zfish   130 ESKDGLREK---QVFDAVMVCTGHHCHPHLP-LKDFPGIDTFKGKFFHSRDYKNPEDWRGKRAVV 190

  Fly   189 IGAGPSGMDLSNIISRTADRVTIS--------HHLTDIG-------------------------- 219
            ||.|.||.|::..:||.|.:|.:|        :.:.|.|
Zfish   191 IGIGNSGGDIAVELSRMAKQVYLSTRKGSWILNRVGDSGVPFDMMFNNRAVMWFLDSLPVKYRNK 255

  Fly   220 -------------------QHSFFE----------------NVQQKPDVRELDEKGAFFVDGSYQ 249
                               :|..|.                .|..||:|:|.......|.||:.:
Zfish   256 LGESRLNKRFDHKLYGLQPEHRIFSQHPMVNDDLPNRILSGTVSVKPNVQEFRGSSVVFEDGTVE 320

  Fly   250 E-FDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGLPFYVCAAQ-MM 310
            : .|.|.|.|||.::||||: ...|.|.:|.| .|||...  .:...::|:|||...:.|.. :.
Zfish   321 DNIDLVVFATGYTFSFPFLS-SHVIPVSNNKV-SLYKFVYPPGLERSTLAVIGLIQPLGAIMPIS 383

  Fly   311 DIQARFIMSYYNGSNELPSTEDMLKDTRDRMGKLWAEGLRKRHA----HMLGPKQIDYFTDLSQT 371
            ::|||:....:.|..:|||...|:||.:.:     .:.:.:|:.    |.:   |:||...:.:.
Zfish   384 EMQARWATRVFKGLCKLPSKNAMMKDIKAK-----EQAMTQRYVAAQRHTI---QVDYIPYMDEL 440

  Fly   372 AGVKNIKPVMTKL 384
            |....::|.:.:|
Zfish   441 AKQVGVRPSIPRL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	74/201 (37%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	11/25 (44%)
si:dkey-239i20.2	NP_001038294.1	FMO-like	2..531	CDD:109787	133/468 (28%)
si:dkey-239i20.2	NP_001038294.1	NADB_Rossmann	7..150	CDD:304358	53/150 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.730