DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and fmo1

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001016366.1	Gene:	fmo1 / 549120	XenbaseID:	XB-GENE-5731297	Length:	539	Species:	Xenopus tropicalis

Alignment Length:	475	Identity:	132/475 - (27%)
Similarity:	210/475 - (44%)	Gaps:	120/475 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPK 68
            |.|||||.:||...:..:..|.|...||.|..|||.|.:.|:..     |..:|:||::.||..|
Frog     5 VAIIGAGCSGLTAIKCCLEEGLEPVCFEKSSDIGGLWRFTESVE-----DWRASIYKSVVTNTSK 64

  Fly    69 EVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQ-----RKTKWQVLF 128
            |:|.:.||.:..:..:|:.:.::.::|..||.||||.|:|:|.:.|..|.:     ...:|.:.
Frog    65 EMMCYTDFPMPEDFPAYLHNSKVLEYLRLYAKHFDLMKYIQFQTEVCSVTKCSDFPSTGQWDIA- 128

  Fly   129 KDLVTNKIE-FQYFDKVLVANGHYHTPNY---SQIPNMERFKGQFLHSHDFRSREVFEGKSVLVI 189
              .:||.|: ...||.||:.||| ||.:|   ...|.:|.|||.::||..::....::||:|||:
Frog   129 --TLTNGIQRNSIFDTVLICNGH-HTKHYLPLDSFPGIENFKGHYVHSRFYKDSANYKGKTVLVV 190

  Fly   190 GAGPSGMDLSNIISRTADRV---------------------------------------TISHHL 215
            |.|.|..|::..||.||.:|                                       :.|..|
Frog   191 GIGNSAGDIAVDISNTAKQVYLSTRGGSWVLSRISKGGCPIDMMLSTRFLTWIRNLLPASFSARL 255

  Fly   216 TDIGQHSFFEN------------------------------VQQKPDVRELDEKGAFFVDGSYQE 250
            .:...:::|::                              ::.||.::...|....|.|.:..|
Frog   256 NENLMNTWFDHANYGLEPLDRAQLKEPMVNDYLPSCILCGAIKVKPQIKTFTESSVIFEDDTVVE 320

  Fly   251 -FDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGL--PF--YVCAAQ 308
             .|.|.|.|||..:||||. |..:..:.|.:  ||||..  .|..|::|::||  |.  .:.||
Frog   321 NLDEVIFATGYVPSFPFLK-DPEVIDDINAL--LYKQVFPTRIEKPTLAVLGLVKPLGAILTAA- 381

  Fly   309 MMDIQARFIMSYYNGSNELPST---EDMLKDTRDRMGKLWAEGLRKRHAHMLGPKQ------IDY 364
              ::|||:....:.|...||:.   ||.:|.:.:...|::|          ..|.|      |||
Frog   382 --ELQARWATRIFKGVAHLPTAARMEDYIKKSMEFKTKVFA----------ATPNQKLQTYFIDY 434

  Fly   365 FTDLSQTAGVK-NIKPVMTK 383
            ..|::...||: ||..::.|
Frog   435 MDDVAVEIGVRPNIMHLLLK 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	70/200 (35%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	12/64 (19%)
fmo1	NP_001016366.1	FMO-like	3..531	CDD:109787	132/475 (28%)
fmo1	NP_001016366.1	NAD_binding_8	7..>58	CDD:290186	21/55 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930