DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fmo-1 and Fmo6

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_006250268.1	Gene:	Fmo6 / 304922	RGDID:	1559491	Length:	532	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	133/458 - (29%)
Similarity:	202/458 - (44%)	Gaps:	104/458 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPK 68
            |.|:|||.:||...|..:..|.|...||.|:.:||.|.::....     :..:|:|:::.||..|
  Rat     5 VAIVGAGVSGLAAIRCCLEEGLEPICFERSNDVGGLWKFSSHVE-----EGRASIYQSVFTNSSK 64

  Fly    69 EVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQRKT-----KWQVLF 128
            |:|.||||....:..:|:...::.:::..:|...||.::|:|::.|..:.:..:     :|.|:.
  Rat    65 EMMCFPDFPYPDDFPNYMHHSKLQEYIKSFAQKKDLLRYIQFETLVSSIKKCSSFLTTGQWVVVT 129

  Fly   129 -KDLVTNKIEFQYFDKVLVANGHYHTPNY--SQIPNMERFKGQFLHSHDFRSREVFEGKSVLVIG 190
             ||   .|.|...||.|::.:||:..||.  ...|.:|.|:|:.:||.|::....|:||.|||||
  Rat   130 EKD---GKQESVLFDAVMICSGHHVYPNMPTDSFPGLEHFQGKCMHSRDYKGPGDFQGKKVLVIG 191

  Fly   191 AGPSGMDLSNIISRTADRVTISHHLTDIGQ---------------------HSFFEN-------- 226
            .|.|..|::..:||.|.:|.||   |..|.                     .||..|
  Rat   192 LGNSASDIAVEVSRLATQVIIS---TRSGSWVMSRVWNDGYPWDMVYVTRFASFLRNILPSFVSD 253

  Fly   227 -------------------------------------------VQQKPDVRELDEKGAFFVDGS- 247
                                                       |..||.|.:..|..|.|.||:
  Rat   254 WLYVKKMNTWFKHENYGLMPLNGPLRKEPVFNDELPARILCGTVSIKPIVTKFTETSAVFEDGTV 318

  Fly   248 YQEFDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGLPFYVCAA-QM 309
            ::..|.|.|.|||.||:|||. ||.|...:|.| .|||...  .:..|:||:|||...:.|| ..
  Rat   319 FEAIDCVIFATGYGYAYPFLE-DSIIKSRNNEV-TLYKGIFPPQLEKPTMAVIGLVQSLGAAIPT 381

  Fly   310 MDIQARFIMSYYNGSNELPSTEDMLKDTRDRMGK--LWAEGLRKRHAHMLGPKQIDYFTDLSQTA 372
            .|:|||:....:..:..||:|.:|:.|..::|||  .|.     ..:|.|....|.|..:||...
  Rat   382 ADLQARWAAKVFTNACVLPTTNEMMDDIDEKMGKKLKWF-----GQSHTLQTDYITYMDELSSFI 441

  Fly   373 GVK 375
            |.|
  Rat   442 GAK 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	63/199 (32%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	12/25 (48%)
Fmo6	XP_006250268.1	FMO-like	2..532	CDD:109787	133/458 (29%)
Fmo6	XP_006250268.1	NADB_Rossmann	6..220	CDD:304358	72/224 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3468
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm9017
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.710