DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and Fmo13

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_008767949.1	Gene:	Fmo13 / 289193	RGDID:	1559819	Length:	536	Species:	Rattus norvegicus

Alignment Length:	471	Identity:	135/471 - (28%)
Similarity:	210/471 - (44%)	Gaps:	104/471 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGL----CCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRT 64
            :.|||||.:||    ||    :..|.|.|.||.|:.|||.|.|.|.|       ....:||:|..
  Rat     6 IAIIGAGVSGLGAIKCC----LEEGLEPTCFEKSNDIGGLWRYEETT-------ERPGIYKSLTC 59

  Fly    65 NLPKEVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQR-----KTKW 124
            |..||:..|.|:.|..:..:|:.:.::.::|..||.||.|.|||:|.:.|.||.:|     ..:|
  Rat    60 NTSKEMTAFSDYPIPDHYPNYMHNSKMMEYLRMYARHFGLMKHIQFQTRVCRVRKRPDFSSSGQW 124

  Fly   125 QVLFKDLVTNKIEFQYFDKVLVANGHYHTPN---YSQIPNMERFKGQFLHSHDFRSREVFEGKSV 186
            .|:.:  |..|.:...||.|:|.:|| .|..   ......:.:|:|::|||.::|..:.|.||.|
  Rat   125 DVVVE--VDGKQKTYVFDGVMVCSGH-STEKCLPLQDFAGISKFQGKYLHSWEYRHPDSFVGKRV 186

  Fly   187 LVIGAGPSGMDLSNIISRTADRVTIS--------HHLTDIG------------------------ 219
            :|||.|.||.|::..||..|::|.:|        :.:.|.|
  Rat   187 VVIGIGNSGADVAGEISHVAEQVFLSTRRGAWIWNRVWDNGNPLDTTLFTRYNRTIQKFYPTFLI 251

  Fly   220 ---------------------QHSFFEN----------------VQQKPDVRELDEKGAFFVDGS 247
                                 :|.|..:                |..||:|:|.....|.|.|||
  Rat   252 NRWAENKLNARFNHANYGLQAKHRFLSHQSIFSDNLPNHIITGRVLVKPNVKEFTPTSAIFEDGS 316

  Fly   248 YQEFDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCINIRNPSMALIGLPFYVCAA-QMMD 311
            .:..|.|.|.|||.::||||. ||...::..:....:.....:..|::|.||:...|.|. ...:
  Rat   317 EEIVDNVVFATGYTFSFPFLD-DSSKILDSEHTMFKFVFPPQLEMPTLAFIGILQPVGATIPTSE 380

  Fly   312 IQARFIMSYYNGSNELPSTEDMLKDTRDRMGKLWAEGLRK-RHAHMLGPKQIDYFTDLSQTAGVK 375
            :|:|::...:.|..:|||..:|:.|...|..|:..|.::. |..|.:  :.|||..:::...|||
  Rat   381 LQSRWVTRVFTGLQKLPSQSNMMADINKRKRKMEKEFVKSPRGIHRV--QYIDYMDEIASELGVK 443

  Fly   376 -NIKPVM---TKLHNE 387
             |:..:.   |||..|
  Rat   444 PNLLSLFLWDTKLAKE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	73/203 (36%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	12/25 (48%)
Fmo13	XP_008767949.1	FMO-like	4..532	CDD:109787	135/471 (29%)
Fmo13	XP_008767949.1	NADB_Rossmann	8..148	CDD:304358	54/152 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345718
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3468
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm9017
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.710