DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and Fmo4

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_653147.2	Gene:	Fmo4 / 246247	RGDID:	628601	Length:	560	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	114/465 - (24%)
Similarity:	191/465 - (41%)	Gaps:	107/465 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPK 68
            |.:||||.:||...:..:....|.|.||.|...||.|.:.||:.     |..:.:|::|.||:.|
  Rat     5 VAVIGAGVSGLSSIKCCLDENLEPTCFERSSDFGGLWKFAEASE-----DGMTRVYRSLVTNVCK 64

  Fly    69 EVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQRKT-----KWQVLF 128
            |:..:.||....:..:::..::..|:|.::|.||.|.|:|:|.:.|..|.:|..     :|:|:.
  Rat    65 EMSCYSDFPFHEDYPNFMSHEKFWDYLREFAEHFGLLKYIRFKTTVRSVTKRPDFSETGQWEVVT 129

  Fly   129 KDLVTNKIEFQYFDKVLVANGHYHTPN--YSQIPNMERFKGQFLHSHDFRSREVFEGKSVLVIGA 191
            :  ...|.:...||.|:|..|.:.:|.  ....|.:.:||||.|||.::|..:.|.||.:||:|.
  Rat   130 E--TEGKQDRAVFDAVMVCTGQFLSPRLPLESFPGIHKFKGQILHSQEYRIPDAFRGKRILVVGL 192

  Fly   192 GPSGMDLSNIISRTADRVTIS-------------------------------------------H 213
            |.:|.|::..:|..|.:|.:|                                           .
  Rat   193 GNTGGDVAVELSGIAAQVFLSTRTGAWVRSRSSVGGYPLNMMQTRWRNFLAQVLPSRFVSWNQER 257

  Fly   214 HLTDIGQH-------------SFFEN-----------VQQKPDVRELDEKGAFFVDGSYQ-EFDT 253
            .:..|..|             .|..|           :..|..|::..|....|.||:.: ..|.
  Rat   258 QMNKIFNHENYGLSIAKGKKPKFIVNDELPTCILCGKITMKTSVKDFTESSIVFEDGTIEANIDV 322

  Fly   254 VFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGLPFYVCAAQM-MDIQAR 315
            |.|.|||:::|||.............:  |||:..  |:...::|:|||.....:..: .:.|||
  Rat   323 VIFTTGYEFSFPFFEEPLKSLCTKKVI--LYKRVFPPNLERSTLAIIGLISLTGSILVGTEFQAR 385

  Fly   316 FIMSYYNGSNELPSTEDMLKDTRDRMGKLWAEGLRKRHAHMLGPKQ---------IDYFTDLSQT 371
            :....:.|...:|.::           ||.||.::|......|..:         |.|..:|:|.
  Rat   386 WATRVFKGLCNIPPSQ-----------KLMAEAIKKEELIKRGVIKDTSQDKLDFISYMDELTQC 439

  Fly   372 AGVKNIKPVM 381
            .|.|...|::
  Rat   440 IGAKPNIPLL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	63/198 (32%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	9/25 (36%)
Fmo4	NP_653147.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3468
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm9017
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.780