DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and Fmo9

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_766432.1	Gene:	Fmo9 / 240894	MGIID:	3606068	Length:	539	Species:	Mus musculus

Alignment Length:	461	Identity:	128/461 - (27%)
Similarity:	207/461 - (44%)	Gaps:	109/461 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGL----CCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRT 64
            :.:||||.:||    ||    :....|.|.||.:|.|||.|.:.:     |..:...|:|:::..
Mouse     6 IAVIGAGISGLGAIKCC----LDEDLEPTCFERNDDIGGLWKFQK-----NASEKMPSIYRSVTI 61

  Fly    65 NLPKEVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQRKT-----KW 124
            |..||:|.|.||.|..:..:|:.:.::.|:...||..|.|..:|:|.:.|..|.:|..     :|
Mouse    62 NTSKEMMCFSDFPIPDHFPNYMHNSKLMDYFRMYAKRFSLLDYIRFKTTVRSVRKRPDFHIHGQW 126

  Fly   125 QVLFKDLVTNKIEFQYFDKVLVANGHYHTPN--YSQIPNMERFKGQFLHSHDFRSREVFEGKSVL 187
            .|:.:  ...|.|...||.|||.:||:..|:  ....|.:|:|:|.:.||.:::|.|.:.||.::
Mouse   127 DVVVE--TDGKQESLVFDGVLVCSGHHTDPHLPLKSFPGIEKFEGCYFHSREYKSPEDYVGKRII 189

  Fly   188 VIGAGPSGMDLSNIISRTADRVTIS--------HHLTDIGQ----------HSFFE--------- 225
            |:|.|.||:|::..:.|.|.:|.:|        |.:.:.|.          |||.:
Mouse   190 VVGIGNSGVDIAVELGRVAKQVFLSTRRGSWILHRVWNNGYPMDSSFFTRFHSFLQKILTTEAVN 254

  Fly   226 ------------------------------------------NVQQKPDVRELDEKGAFFVDGSY 248
                                                      .||.||:|:|.......|.||:.
Mouse   255 KYLEKTLNSRFNHAHYGLQPQHRPLSQHPTISDDLPNHIISGKVQVKPNVKEFTGTDVHFDDGTV 319

  Fly   249 QE-FDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGL--PFYVCAAQ 308
            :| .|.|.|.|||..:||||  ...|.|.||.| .|||...  ::..|::|:|||  |..: ...
Mouse   320 EENIDVVIFATGYSISFPFL--GDLIAVTDNEV-SLYKLMFPPDLEKPTLAVIGLIQPLGI-ILP 380

  Fly   309 MMDIQARFIMSYYNGSNELPSTEDMLKDTRDRMGKLWAEGLRKRHA----HMLGPKQIDYFTDLS 369
            :.::|:|:.:..:.|.::|||.:.|..|...|     .:.:.||:.    |.:....|:|..:::
Mouse   381 IAELQSRWAVRVFKGLSKLPSVKAMKADMDQR-----KKAMEKRYVKTARHTIQVDHIEYMDEIA 440

  Fly   370 QTAGVK 375
            ..||||
Mouse   441 SLAGVK 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	66/202 (33%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	9/25 (36%)
Fmo9	NP_766432.1	FMO-like	3..531	CDD:109787	128/461 (28%)
		NAD_binding_8	8..>42	CDD:290186	16/37 (43%)
		NADB_Rossmann	<90..>342	CDD:304358	67/255 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3710
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8771
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2115
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.810