DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and FMO5

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001452.2	Gene:	FMO5 / 2330	HGNCID:	3773	Length:	533	Species:	Homo sapiens

Alignment Length:	487	Identity:	132/487 - (27%)
Similarity:	218/487 - (44%)	Gaps:	108/487 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPK 68
            :.:||.|.:||...:..:..|.|...||.:|.|||.|.:.|     |..:..:|:||::..|..|
Human     6 IAVIGGGVSGLSSIKCCVEEGLEPVCFERTDDIGGLWRFQE-----NPEEGRASIYKSVIINTSK 65

  Fly    69 EVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQR-----KTKWQVLF 128
            |:|.|.|:.|..:..:::.:.::.::...||..|||.|:|:|.:.|..|.::     ..:|:|:.
Human    66 EMMCFSDYPIPDHYPNFMHNAQVLEYFRMYAKEFDLLKYIRFKTTVCSVKKQPDFATSGQWEVVT 130

  Fly   129 KDLVTNKIEFQYFDKVLVANGHY---HTPNYSQIPNMERFKGQFLHSHDFRSREVFEGKSVLVIG 190
            :.  ..|.|...||.|:|..||:   |.| ....|.:|:||||:.||.|:::.|.|.||.|::||
Human   131 ES--EGKKEMNVFDGVMVCTGHHTNAHLP-LESFPGIEKFKGQYFHSRDYKNPEGFTGKRVIIIG 192

  Fly   191 AGPSGMDLSNIISRTADRVTISHH-----LTDIGQHSF--------------------------- 223
            .|.||.||:..||:||.:|.:|..     |..:|.:.:
Human   193 IGNSGGDLAVEISQTAKQVFLSTRRGAWILNRVGDYGYPADVLFSSRLTHFIWKICGQSLANKYL 257

  Fly   224 -------FEN------------------------------VQQKPDVRELDEKGAFFVDGSYQ-E 250
                   |::                              |:.|.:|:|..|..|.|.|||.: :
Human   258 EKKINQRFDHEMFGLKPKHRALSQHPTLNDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSREDD 322

  Fly   251 FDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGLPFYVCAAQ-MMDI 312
            .|.|.|.|||.:.||||  :..:.|..|.: .|||:..  |:..|::|:|||...:.|.. :.::
Human   323 IDAVIFATGYSFDFPFL--EDSVKVVKNKI-SLYKKVFPPNLERPTLAIIGLIQPLGAIMPISEL 384

  Fly   313 QARFIMSYYNGSNELPSTEDMLKD---TRDRMGKLWAEGLRKRHAHMLGPKQIDYFTDLSQTAGV 374
            |.|:....:.|...|||..:|:.:   .::.:.|.:.|..|    |.:   |.||...:.:.|.:
Human   385 QGRWATQVFKGLKTLPSQSEMMAEISKAQEEIDKRYVESQR----HTI---QGDYIDTMEELADL 442

  Fly   375 KNIKPVMTKLHNESSKCFNENLL------HFR 400
            ..::|.:..|.....|.....||      |:|
Human   443 VGVRPNLLSLAFTDPKLALHLLLGPCTPIHYR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	67/199 (34%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	13/25 (52%)
FMO5	NP_001452.2	FMO-like	3..532	CDD:109787	132/487 (27%)
FMO5	NP_001452.2	NAD_binding_8	8..>43	CDD:290186	13/34 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3793
Isobase	1	0.950	-	0	Normalized mean entropy	S2686
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8542
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2115
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.760