DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and FMO3

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001002294.1	Gene:	FMO3 / 2328	HGNCID:	3771	Length:	532	Species:	Homo sapiens

Alignment Length:	461	Identity:	132/461 - (28%)
Similarity:	204/461 - (44%)	Gaps:	110/461 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPK 68
            |.|||||.:||...|..:..|.|.|.||.|:.|||.|.:::     :..:..:|:||::.:|..|
Human     5 VAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSD-----HAEEGRASIYKSVFSNSSK 64

  Fly    69 EVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQRKT-----KWQVLF 128
            |:|.||||....:..:::.:.:|.:::..:|...:|.|:|:|.::|..|.:...     :|
Human    65 EMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQW---- 125

  Fly   129 KDLVT---NKIEFQYFDKVLVANGHYHTPNY--SQIPNMERFKGQFLHSHDFRSREVFEGKSVLV 188
             |:.|   .|.|...||.|:|.:||:..||.  ...|.:..|||:..||.|::...||.||.|||
Human   126 -DVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLV 189

  Fly   189 IGAGPSGMDLSNIISRTADRVTISHH--------------------LTDIGQHSFFEN------- 226
            :|.|.||.|::..:||||::|.||..                    :|..|  :|.:|
Human   190 VGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFG--TFLKNNLPTAIS 252

  Fly   227 --------------------------------------------VQQKPDVRELDEKGAFFVDGS 247
                                                        |..||:|:|..|..|.|.||:
Human   253 DWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGT 317

  Fly   248 -YQEFDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCIN--IRNPSMALIGLPFYVCAA-Q 308
             ::..|.|.|.|||.:|:|||  |..|....|....|:|....  :...::|:||....:.|| .
Human   318 IFEGIDCVIFATGYSFAYPFL--DESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIP 380

  Fly   309 MMDIQARFIMSYYNGSNELPSTEDMLKDTRDRMGKLWAEGLRKR----HAHMLGPKQIDYFTDLS 369
            .:|:|:|:......|:..|||.|||:.|..::|.|       ||    .:..:....|.|..:||
Human   381 TVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEK-------KRKWFGKSETIQTDYIVYMDELS 438

  Fly   370 QTAGVK 375
            ...|.|
Human   439 SFIGAK 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	68/201 (34%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	13/25 (52%)
FMO3	NP_001002294.1	FMO-like	2..532	CDD:109787	132/461 (29%)
FMO3	NP_001002294.1	NAD_binding_8	7..>41	CDD:290186	17/33 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3793
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8542
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780