DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and FMO2

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001451.2	Gene:	FMO2 / 2327	HGNCID:	3770	Length:	535	Species:	Homo sapiens

Alignment Length:	461	Identity:	135/461 - (29%)
Similarity:	209/461 - (45%)	Gaps:	108/461 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPK 68
            |.:||||.:||...:..:..|.|.|.||.::.|||.|.:.|     |..|..:|:|:::.||..|
Human     5 VAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKE-----NVEDGRASIYQSVVTNTSK 64

  Fly    69 EVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQRKT-------KWQV 126
            |:..|.||.:..:..:::.:.::.::...:|..|||.|:|:|.:.|:.|  ||.       :|:|
Human    65 EMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSV--RKCPDFSSSGQWKV 127

  Fly   127 LFKDLVTNKIEFQYFDKVLVANGHYHTPN--YSQIPNMERFKGQFLHSHDFRSREVFEGKSVLVI 189
            :.:.  ..|.:...||.|:|.:||:..|:  ....|.|||||||:.||..::..:.||||.:|||
Human   128 VTQS--NGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPDGFEGKRILVI 190

  Fly   190 GAGPSGMDLSNIISRTADRVTIS-HHLT-------------DIGQHSFF---------------- 224
            |.|.||.|::..:|:.|.:|.|| .|.|             |...|:.|
Human   191 GMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWM 255

  Fly   225 -----------EN----------------------------VQQKPDVRELDEKGAFFVDGSYQE 250
                       ||                            ::.|..|:||.|..|.|.||:.:|
Human   256 IEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEE 320

  Fly   251 -FDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGL-----PFYVCAA 307
             .|.:.|.|||.::||||. ||.:.||:|.| .|||...  ::...::|.|||     ..:..|
Human   321 NIDVIIFATGYSFSFPFLE-DSLVKVENNMV-SLYKYIFPAHLDKSTLACIGLIQPLGSIFPTA- 382

  Fly   308 QMMDIQARFIMSYYNGSNELPSTEDMLKDTRDRMGK---LWAEGLRKRHAHMLGPKQIDYFTDLS 369
               ::|||::...:.|...|||...|:.|...|..|   |:.|.    .:..|....:||..:|:
Human   383 ---ELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFGES----QSQTLQTNYVDYLDELA 440

  Fly   370 QTAGVK 375
            ...|.|
Human   441 LEIGAK 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	69/200 (35%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	11/25 (44%)
FMO2	NP_001451.2	FMO-like	2..532	CDD:109787	135/461 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3793
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8542
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2115
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.810