DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fmo-1 and FMO1

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001269621.1	Gene:	FMO1 / 2326	HGNCID:	3769	Length:	536	Species:	Homo sapiens

Alignment Length:	467	Identity:	126/467 - (26%)
Similarity:	199/467 - (42%)	Gaps:	115/467 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGLCCARHSIANGFETTVFELSDRIGGTWVYNEATGAVNGIDVHSSMYKNLRTNLPK 68
            |.|:|||.:||...:..:..|.|.|.||.||.:||.|.:.|...     :..:|:||::.:|..|
Human     9 VAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVE-----EGRASLYKSVVSNSCK 68

  Fly    69 EVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQRKT-----KWQVLF 128
            |:..:.||....:..:||.:.:..::|..|||||||.|||:|.:.|..|.:...     :|:|:
Human    69 EMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVV- 132

  Fly   129 KDLVTNKIEFQYFDKVLVANGHYHTP--NYSQIPNMERFKGQFLHSHDFRSREVFEGKSVLVIGA 191
             .:...|.|...||.|:|..|....|  .....|.:..||||:.||..::..::|:.|.|||||.
Human   133 -TMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGM 196

  Fly   192 GPSGMDLSNIISRTADRVTIS--------HHLTDIGQ------HSFFENVQQ------------- 229
            |.||.|::...|..|::|.:|        ..:.|.|.      .:.|:|:.:
Human   197 GNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQNMLRNSLPTPIVTWLME 261

  Fly   230 ------------------------------------------KPDVRELDEKGAFFVDGSYQE-F 251
                                                      :|.::|:.|....|.:.|.:| .
Human   262 RKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEPI 326

  Fly   252 DTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCI--NIRNPSMALIGL--PFYVCAAQMM-- 310
            |.:.|.|||.:|||||. :|.:.|||... .|||...  :::.|::|:|||  |.    ..|:
Human   327 DIIVFATGYTFAFPFLD-ESVVKVEDGQA-SLYKYIFPAHLQKPTLAIIGLIKPL----GSMIPT 385

  Fly   311 -DIQARFIMSYYNGSNELPSTEDMLKDTRDR-------MGKLWAEGLRKRHAHMLGPKQIDYFTD 367
             :.|||:.:....|.|:||....|:::...|       .|..:.:.|           |.||.|.
Human   386 GETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWFGLCYCKAL-----------QSDYITY 439

  Fly   368 LSQTAGVKNIKP 379
            :.:.....|.||
Human   440 IDELLTYINAKP 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	68/198 (34%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	12/25 (48%)
FMO1	NP_001269621.1	FMO-like	6..536	CDD:109787	126/467 (27%)
FMO1	NP_001269621.1	NADB_Rossmann	10..214	CDD:304358	71/210 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3793
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8542
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780