DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-1 and Gm4847

DIOPT Version :9

Sequence 1:	NP_611859.1	Gene:	Fmo-1 / 37814	FlyBaseID:	FBgn0034943	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001157784.1	Gene:	Gm4847 / 226604	MGIID:	3643320	Length:	537	Species:	Mus musculus

Alignment Length:	479	Identity:	135/479 - (28%)
Similarity:	215/479 - (44%)	Gaps:	117/479 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VCIIGAGTAGL----CCARHSIANGFETTVFELSDRIGGTWVYNEATGAVN-GIDVHSSMYKNLR 63
            :.:||||.:||    ||    :..|.|.|.||....|||.|.|.|...:.| ||      ||:|.
Mouse     6 IAVIGAGVSGLGAIKCC----LEEGLEPTCFEKKSDIGGLWKYEEIPKSGNLGI------YKSLT 60

  Fly    64 TNLPKEVMGFPDFEIGANEASYVRSDEICDFLNQYANHFDLKKHIKFDSYVIRVLQR-----KTK 123
            .|..||:..|.|:.|..:..:|:...::.::|..||.||.|.|||:|.:.|..:.:|     ..:
Mouse    61 CNTSKEMTAFSDYPIPDHYPNYMHHSKMMEYLRMYARHFGLMKHIQFQTNVCNIKKRPDFSSSGQ 125

  Fly   124 WQVLFKDLVTNKIEFQY-FDKVLVANGHYHTPNYSQIPNME---RFKGQFLHSHDFRSREVFEGK 184
            |.|:.:   |.:::..| ||.::|.:||| |..|..:.:.|   :|:|.:||:.:::..:.|.||
Mouse   126 WDVVVE---TEEMQKTYIFDGIMVCSGHY-TEKYFPLQDFEGISKFQGSYLHTWEYKHPDNFVGK 186

  Fly   185 SVLVIGAGPSGMDLSNIISRTADRVTIS--------HHLTDIGQ--------------------- 220
            .|.|||.|.||.|::..|||.||:|.:|        :.:.|.|:
Mouse   187 RVAVIGLGNSGADVAGEISRVADQVFLSTRQGAWIWNRVWDHGEPMDTTVFTRYNRAVQKICPRY 251

  Fly   221 ------------------------HSFFE----------------NVQQKPDVRELDEKGAFFVD 245
                                    |...|                .|:.||:|:|.....|.|.|
Mouse   252 IINRQMEKKLNGRFNHANYGLLPTHRILEQRTVLSDDLPNRIIIGKVKIKPNVKEFTSTSAIFED 316

  Fly   246 GSYQEFDTVFFCTGYKYAFPFLTVDSGIYVEDNYVQELYKQCINIRNPSMALIG--------LPF 302
            |:.:..|.|.|.||||.:||||:.|||: :::.|....|.....:..|::|.||        ||
Mouse   317 GTKENIDVVIFATGYKLSFPFLSDDSGV-LDNQYSMFKYVFPPELEKPTLAFIGILQPAGAILP- 379

  Fly   303 YVCAAQMMDIQARFIMSYYNGSNELPSTEDMLKDTRDRMGKLWAEGLRKRHAHMLGPKQIDYFTD 367
                  ..::|:|:::..:.|..:|||...|:.|...:..::.|:|.:|..........:||..:
Mouse   380 ------TSELQSRWVVHVFKGIKKLPSRRAMIADINRKNHQIMAKGSKKILQDHRRVTFVDYMDE 438

  Fly   368 LSQTAGVK-NIKPVM---TKLHNE 387
            ::...||| |:..::   |||..|
Mouse   439 IASEIGVKPNLLSLLLWDTKLAKE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-1	NP_611859.1	NADB_Rossmann	5..197	CDD:304358	71/205 (35%)
Fmo-1	NP_611859.1	NADB_Rossmann	185..>211	CDD:304358	14/25 (56%)
Gm4847	NP_001157784.1	FMO-like	4..516	CDD:109787	135/479 (28%)
Gm4847	NP_001157784.1	NAD_binding_8	8..>48	CDD:290186	19/43 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3710
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8771
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2115
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.740