DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TRIM74 and Trim50

DIOPT Version :9

Sequence 1:	NP_001304744.1	Gene:	TRIM74 / 378108	HGNCID:	17453	Length:	250	Species:	Homo sapiens
Sequence 2:	XP_006249190.1	Gene:	Trim50 / 288596	RGDID:	631346	Length:	484	Species:	Rattus norvegicus

Alignment Length:	250	Identity:	201/250 - (80%)
Similarity:	218/250 - (87%)	Gaps:	0/250 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAWQVSLLELEDWLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVRCPMCWQVVDGSSS 65
            ||||:::.||:|.||||||||||||.|||||||||||.||.|||.|||:::|||:|.|.||.|||
  Rat     1 MAWQLTVPELQDQLQCPICLEVFKEPLMLQCGHSYCKNCLDSLSEHLDSELRCPVCRQSVDCSSS 65

Human    66 LPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVCS 130
            .||||||.||:|||||||.||.||||||||||||||||||.||||||||||||||.|||||||.|
  Rat    66 PPNVSLARVIDALRLPGDTEPTVCVHHRNPLSLFCEKDQEFICGLCGLLGSHQHHRVTPVSTVYS 130

Human   131 RMKEELAALFSELKQEQKKVDELIAKLVKNRTRIVNESDVFSWVIRREFQELRHPVDEEKARCLE 195
            |||||||...||||::.:.|:|.|.|||.|||||:|||||||||||||||||.|.||||||||||
  Rat   131 RMKEELAGRLSELKEQHRDVEEHIGKLVNNRTRIINESDVFSWVIRREFQELHHLVDEEKARCLE 195

Human   196 GIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHEFIWKFHSMASR 250
            |:..|||||||||||||||||||:|||||||.||||||||.|||||.||||:.||
  Rat   196 GVESHTRGLVASLDMQLEQAQGTQERLAQAERVLEQFGNESHHEFIRKFHSITSR 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRIM74	NP_001304744.1	RING	15..60	CDD:238093	35/44 (80%)
TRIM74	NP_001304744.1	BBOX	90..125	CDD:237988	32/34 (94%)
Trim50	XP_006249190.1	RING	15..60	CDD:238093	35/44 (80%)
		BBOX	90..125	CDD:237988	32/34 (94%)
		iSH2_PI3K_IA_R	134..>225	CDD:304922	71/90 (79%)
		SPRY_PRY_TRIM50	283..471	CDD:293977
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I45153
eggNOG	1	0.900	-	-		E33208_3BG6H
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124751at32523
OrthoFinder	1	1.000	-	-		FOG0008511
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24103
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880