DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TRIM74 and LOC100536643

DIOPT Version :9

Sequence 1:	NP_001304744.1	Gene:	TRIM74 / 378108	HGNCID:	17453	Length:	250	Species:	Homo sapiens
Sequence 2:	XP_003198215.2	Gene:	LOC100536643 / 100536643	-ID:	-	Length:	466	Species:	Danio rerio

Alignment Length:	247	Identity:	60/247 - (24%)
Similarity:	108/247 - (43%)	Gaps:	34/247 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    11 EDWLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVR-CPMCWQVVDGSSSLPNVSLAWV 74
            |:.|.||:|.|:|::.::|.|.||:|:.||.  .:.....:| ||:|.:.....|...|.:|..:
Zfish     7 EEDLSCPVCCEIFQDPVLLPCSHSFCRRCLE--RFWKSALLRSCPVCRRRASKKSPPSNRALKNL 69

Human    75 IEALRL---PGDPEPK--VCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVCSRMKE 134
            .||.:|   .|:....  :|..|...|.|||..|||.||.:|.....|:.|..:|........|:
Zfish    70 CEAFQLGKGQGNASGSNLLCWRHGEKLKLFCLVDQEPICVVCQASKMHKGHDCSPTEEAALECKD 134

Human   135 ELAALFSELKQ------EQKKVDELIAKLVKNRTRIVNESDVFSWVIRREFQELRH--------- 184
            ::::....|:|      :.::....|.:.:|.:.:.|...      ::.||.:|..
Zfish   135 KISSAIMVLQQKLEVFNKARQSSAFILEHIKTQAQRVERQ------MKEEFLKLHQFLYAEEERR 193

Human   185 --PVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAE--CVLEQF 232
              .:.||:.:|:..:.........|:. .|.:...|.|:..:||  .:|:.|
Zfish   194 LSALKEEEEQCVTAVKSRDEDYTRSIG-SLTELINTMEQTLKAEDLTLLQNF 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRIM74	NP_001304744.1	RING	15..60	CDD:238093	16/45 (36%)
TRIM74	NP_001304744.1	BBOX	90..125	CDD:237988	13/34 (38%)
LOC100536643	XP_003198215.2	RING	12..53	CDD:238093	16/42 (38%)
		BBOX	88..124	CDD:237988	14/35 (40%)
		SPRY_PRY_TRIM35	291..457	CDD:293950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D158777at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920