Protein Alignment thoc5 and THOC5

DIOPT Version :10

• Sequence 1: NP_611856.1
• Gene: thoc5 / 37810
• FlyBaseID: FBgn0034939
• Length: 616
• Species: Drosophila melanogaster
• Sequence 2: XP_005261854.1
• Gene: THOC5 / 8563
• HGNCID: 19074
• Length: 694
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 189/646 - (29%)
• Similarity: 301/646 - (46%)
• Gaps: 73/646 - (11%)

  Fly    11 QLQKAIEGIKEAKSKGQ-----STDEARIATTLMFVALKHANREVKHKIKAGRDKLHLEKCKVDL 70
            :||:.:..|::.||:|.     ..:|.||.:.:.|:.||..||....::|.|||:.|..|.|||.
Human    61 ELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDA 125

  Fly    71 SRLQLQNLLYEVSHLKKEIVRCQKFKSRDTSLELLSEAEYSSELPDMPNDAEEL--SSHKQHLHR 133
            ..||||||||||.||:|||.:|.:|||:...::|:|..|:..|.|...:.||..  ..|:|.|.|
Human   126 YHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTMGDPHQQTLAR 190

  Fly   134 LDCELRLRKALDKQYSALLSSKQELLQDNLSHAQRYVSFAPALRTLQSATKPLHDALQLSLDVEW 198
            ||.||..||.|.::|...||:|:::|::.....:...|..|.|.::..|:.|:.:.|.:..|...
Human   191 LDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAH 255

  Fly   199 KLSAVVKYLPKPLYVLFIV----------LQSLQRVSEEQSFTAEVVGYESEAQMQELLKEKKCS 253
            |.....::||.||||||:.          ::|.|...::::.:..:.|...||  :.|.|..:.|
Human   256 KQYETARHLPPPLYVLFVQATAYGQACAHMKSSQPPRQDKTLSVAIEGSVDEA--KALFKPPEDS 318

  Fly   254 TLNYRQTKKESGDREKIADKN-------NLDDS----LAPHPLHICLTIGAAGSNQLVLQIRYFD 307
                :..:.:|...|:...|.       .|||.    |..|||.:.|.:.....:.|.|...|..
Human   319 ----QDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLM 379

  Fly   308 FIKCATVWGQLNCSR---NANGQGDTNFVHHLLRHLYPNDLGNELPIPGIQYELRSSDLTAEECV 369
            .:...||..::..:.   .....||......:|..|||.|.|.:.|.|..||:.        :.|
Human   380 NLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQF--------DKV 436

  Fly   370 RYLKAKDY----GKPFCWLQSMCSI----ATVNSSMLYKHEL---NLNKNNKEIIDRIARRLNSW 423
            ..|...||    |.|:.|:|.:..:    .....:::..|.|   ::....|.:..|:..||
Human   437 GILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLKTRVQSRL--- 498

  Fly   424 QRLSQQIRGLTFKDIDLYSLQENIYPAGLSCSLVQWTAITHE---ELHSQISDALNSSSADKGIT 485
             .|.:|...|....:.:.|..:.::||.:...||:|..:.||   |||. ..|.:::..|  |.|
Human   499 -ALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHF-TKDIVDAGLA--GDT 559

  Fly   486 YNSYRAVIVRGSAKMECFIRIPSNYPLEMPLWILNVHWNGCLTAQNNSAIKMMEFWTNSLQPKHL 550
            ...|.|:|.||:||::..:.:...|....|::.|.::|.|..|..|:..|:.||...|... |.|
Human   560 NLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCY-KEL 623

  Fly   551 ---EPNDCILYAQLFRTIYSFDIFLETEG---SMQNTIEYNKEKPYISAFAKRSRSRPYKY 605
               .|:..:|..||.|.....|::||||.   |::...|:.:||..:..|...||.:|:||
Human   624 CGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMKPFKY 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
thoc5	NP_611856.1	FmiP_Thoc5	48..392	CDD:462889	112/377 (30%)
THOC5	XP_005261854.1	FmiP_Thoc5	103..463	CDD:462889	112/373 (30%)