DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment thoc5 and thoc5

DIOPT Version :9

Sequence 1:	NP_611856.1	Gene:	thoc5 / 37810	FlyBaseID:	FBgn0034939	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_031755969.1	Gene:	thoc5 / 549581	XenbaseID:	XB-GENE-1015168	Length:	696	Species:	Xenopus tropicalis

Alignment Length:	648	Identity:	179/648 - (27%)
Similarity:	296/648 - (45%)	Gaps:	78/648 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LQKAIEGIKEAKSKG-----QSTDEARIATTLMFVALKHANREVKHKIKAGRDKLHLEKCKVDLS 71
            ||:.:..|::.|:||     ...:|.::.:.:.|:.||..||....::|..||:.|..|.|||..
Frog    63 LQRLMSEIQDLKNKGGKDSAMEIEEKKVQSCVHFMTLKKLNRLAHIRLKKARDQTHEAKQKVDAY 127

  Fly    72 RLQLQNLLYEVSHLKKEIVRCQKFKSRDTSLELLSEAEYSSELPDMPNDAEELS--SHKQHLHRL 134
            .||||||||||.||:|||.:|.:|||:...:||:|..|:.||.|...:..|..|  ||:|.|.||
Frog   128 HLQLQNLLYEVMHLQKEITKCLEFKSKHEEIELVSVEEFYSEAPATISKPEITSTDSHQQTLSRL 192

  Fly   135 DCELRLRKALDKQYSALLSSKQELLQDNLSHAQRYV-SFAPALRTLQSATKPLHDALQLSLDVEW 198
            |.||..||.|.::|...|:||:::|:: :...:.|: |..|.|.::..|:.|:.:.|.:..|...
Frog   193 DWELEQRKRLAEKYKECLASKEKILKE-IEIKKEYLNSLQPQLNSIMQASLPVQEYLSMPFDCMH 256

  Fly   199 KLSAVVKYLPKPLYVLFIVLQS-----------LQRVSEEQSFTAEVVGYESEAQMQELLKEKKC 252
            |.....::||.||||||:...:           .|...:::.....:.|...||  :.|.|..:.
Frog   257 KQYETARHLPPPLYVLFVQASAYSQACAHMKSYAQPCRQDRKLVVTIEGNVEEA--RALFKPPED 319

  Fly   253 STLNYRQTKKESGDREKIADKN-------NLDDS----LAPHPLHICLTIGAAGSNQLVLQIRYF 306
            |    :..:.:|...|:...|.       .|||.    |..|||.:.||:.....:.|.|...:.
Frog   320 S----QDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLCVTLTLKCKEGSTLNLTFYFL 380

  Fly   307 DFIKCATVWGQLNCS---RNANGQGDTNFVHHLLRHLYPNDLGNELPIPGIQYELRSSDLTAEEC 368
            ..:...||..::..:   ..|...||......:|..||..|.|...|.|..:|:.        :.
Frog   381 MNLNILTVKVKIQPALELSTAISAGDLLNPDLILSCLYQGDDGKTTPNPANRYQF--------DK 437

  Fly   369 VRYLKAKDY----GKPFCWLQSMCSI---------ATVNSSMLYKHELNLNKNNKEIIDRIARRL 420
            :..|...||    |.|:.|:|:|..:         |.:..:.|....:      ::.|:.:..||
Frog   438 IGILSLNDYISELGHPYIWVQTMGGLHFPTDQPQPAVIADNALSASHM------EKTINLLRARL 496

  Fly   421 NSWQRLSQQIRGLTFKDIDLYSLQENIYPAGLSCSLVQWTAITHEELHS--QISDALNSSSADKG 483
            .|...|.:|...|....|.:....:.::||.:...|.:|..||:|:..:  ...|.:....|.:.
Frog   497 LSRLSLHRQFASLEHGSIPVSLECQTLFPAKVISRLTKWNVITYEDYLALPYTKDVIECGLAKET 561

  Fly   484 ITYNSYRAVIVRGSAKMECFIRIPSNYPLEMPLWILNVHWNGCLTAQNNSAIKMMEFWTNSLQPK 548
            ..|  :..:|.||:||:...:.:...|....|::.|.::|.|..::.|:..|::||...| :..|
Frog   562 DQY--FYLLIERGTAKLNGVVVLNPGYCAVPPVFSLCLNWKGERSSSNDDNIRVMESEVN-VYFK 623

  Fly   549 HL---EPNDCILYAQLFRTIYSFDIFLETE---GSMQNTIEYNKEKPYISAFAKRSRSRPYKY 605
            .|   .|...:|..|:.|.....|::||||   .|::...|:..||..:......||::|:||
Frog   624 ELCGPPPGFQLLTNQIQRLCMLLDVYLETERHDNSVEGPHEFPPEKICLRLLRGPSRTKPFKY 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
thoc5	NP_611856.1	FimP	42..392	CDD:286807	116/390 (30%)
thoc5	XP_031755969.1	pneumo_PspA	5..>198	CDD:411490	60/141 (43%)
thoc5	XP_031755969.1	FimP	104..465	CDD:401641	114/401 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I4542
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37836
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3639
OMA	1	1.010	-	-		QHG52356
OrthoDB	1	1.010	-	-		D1048314at2759
OrthoFinder	1	1.000	-	-		FOG0004183
OrthoInspector	1	1.000	-	-		otm48403
Panther	1	1.100	-	-	LDO	PTHR13375
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3051
SonicParanoid	1	1.000	-	-		X4566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110