Protein Alignment thoc5 and Thoc5

DIOPT Version :10

• Sequence 1: NP_611856.1
• Gene: thoc5 / 37810
• FlyBaseID: FBgn0034939
• Length: 616
• Species: Drosophila melanogaster
• Sequence 2: NP_001388336.1
• Gene: Thoc5 / 360972
• RGDID: 1304991
• Length: 694
• Species: Rattus norvegicus
• Alignment Length: 651
• Identity: 190/651 - (29%)
• Similarity: 299/651 - (45%)
• Gaps: 83/651 - (12%)

  Fly    11 QLQKAIEGIKEAKSKGQ-----STDEARIATTLMFVALKHANREVKHKIKAGRDKLHLEKCKVDL 70
            :||:.:..|::.||||.     ..:|.||.:.:.|:.||..||....::|.|||:.|..|.|||.
  Rat    61 ELQRLMAEIQDLKSKGSKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDA 125

  Fly    71 SRLQLQNLLYEVSHLKKEIVRCQKFKSRDTSLELLSEAEYSSELPDMPNDAEEL--SSHKQHLHR 133
            ..||||||||||.||:|||.:|.:|||:...::|:|..|:.||.|...:.||..  ..|:|.|.|
  Rat   126 YHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYSEAPPNISKAEITMGDPHQQTLAR 190

  Fly   134 LDCELRLRKALDKQYSALLSSKQELLQDNLSHAQRYVSFAPALRTLQSATKPLHDALQLSLDVEW 198
            ||.||..||.|.::|...||:|:::|::.....:...|..|.|.::..|:.|:.:.|.:..|...
  Rat   191 LDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAH 255

  Fly   199 KLSAVVKYLPKPLYVLFIV----------LQSLQRVSEEQSFTAEVVGYESEAQMQELLKEKKCS 253
            |.....::||.||||||:.          :.|.|...::::.:..:.|...||  :.|.|..:.|
  Rat   256 KQYETARHLPPPLYVLFVQATAYGQACAHMTSSQPPRQDKTLSVAIEGSVDEA--KALFKPPEDS 318

  Fly   254 TLNYRQTKKESGDREKIADKN-------NLDDS----LAPHPLHICLTIGAAGSNQLVLQIRYFD 307
                :..:.:|...|:...|.       .|||.    |..|||.:.|.:....::.|.|...|..
  Rat   319 ----QDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDNSVLHLTFFYLM 379

  Fly   308 FIKCATVWGQLNCSR---NANGQGDTNFVHHLLRHLYPNDLGNELPIPGIQYELRSSDLTAEECV 369
            .:...||..::..:.   .....||......:|..|||.|.|.:.|.|..||:.        :.|
  Rat   380 NLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQF--------DKV 436

  Fly   370 RYLKAKDY----GKPFCWLQSMCSI----------ATVNSSMLYKHELNLNKNNKEIIDRIARRL 420
            ..|..:||    |.|:.|:|.:..:          ...:.|....|   :....|.:..|:..||
  Rat   437 GILTLRDYVLELGHPYLWVQKLGGLHFPKEQPQHTVMADHSQSASH---METTMKLLKTRVQSRL 498

  Fly   421 NSWQRLSQQIRGLTFKDIDLYSLQENIYPAGLSCSLVQWTAITHE---ELHSQISDALNSSSADK 482
                .|.:|...|....:.:.|..:.::||.:...||:|..:.||   |||. ..|.:.:..|
  Rat   499 ----ALHKQFASLEHGIVPVTSECQYLFPAKVVSRLVKWMIMAHEDYMELHF-TKDIVEAGLA-- 556

  Fly   483 GITYNSYRAVIVRGSAKMECFIRIPSNYPLEMPLWILNVHWNGCLTAQNNSAIKMMEFWTNSLQ- 546
            |.|...|.|:|.||:||::..:.:...|....|::.|.::|.|..|..|:..|:.||...|...
  Rat   557 GDTNLYYLALIERGTAKLQAAVVLNPGYSSIPPVFRLCLNWKGEKTNSNDDNIRAMESEVNVCYR 621

  Fly   547 ----PKHLEPNDCILYAQLFRTIYSFDIFLETEG---SMQNTIEYNKEKPYISAFAKRSRSRPYK 604
                |:   |:..:|..||.|.....|::||||.   |::...|:.:||..:..|...||.:|:|
  Rat   622 ELCGPR---PSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMKPFK 683

  Fly   605 Y 605
            |
  Rat   684 Y 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
thoc5	NP_611856.1	FmiP_Thoc5	48..392	CDD:462889	113/383 (30%)
Thoc5	NP_001388336.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42
		Interaction with THOC7. /evidence=ECO:0000250|UniProtKB:Q13769	2..199		59/137 (43%)
		Interaction with CSF1R. /evidence=ECO:0000250|UniProtKB:Q8BKT7	2..144		37/82 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	7..10
		FmiP_Thoc5	103..463	CDD:462889	113/373 (30%)