DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment thoc5 and thoc5

DIOPT Version :9

Sequence 1:	NP_611856.1	Gene:	thoc5 / 37810	FlyBaseID:	FBgn0034939	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_005174290.1	Gene:	thoc5 / 325064	ZFINID:	ZDB-GENE-030131-3789	Length:	705	Species:	Danio rerio

Alignment Length:	636	Identity:	182/636 - (28%)
Similarity:	301/636 - (47%)	Gaps:	65/636 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LQKAIEGIKEAKSKGQSTDEARI-----ATTLMFVALKHANREVKHKIKAGRDKLHLEKCKVDLS 71
            |.|.:..|:|.|:.|.....|.|     .:::.|:.||..||....::|.|||:.|..|.:||:.
Zfish    83 LAKLMSEIQELKTSGAKDGSAEIELRRKQSSIHFITLKKLNRLAHMRLKKGRDQTHEAKQRVDVL 147

  Fly    72 RLQLQNLLYEVSHLKKEIVRCQKFKSRDTSLELLSEAEYSSELP---DMPNDAEELSSHKQHLHR 133
            .||||||||||.||:|||.:|.:|||:...:||:||.|:..:.|   ..|....| ..|:..|.|
Zfish   148 HLQLQNLLYEVMHLQKEIGKCLEFKSQHEEIELVSEDEFFQDAPAEISRPQVTRE-DHHQLTLAR 211

  Fly   134 LDCELRLRKALDKQYSALLSSKQELLQDNLSHAQRYV-SFAPALRTLQSATKPLHDALQLSLDVE 197
            ||.||..||.|.:||...|||| |.:|..:...:.|: |..|.|..:..|:.|:.:.|.:..:..
Zfish   212 LDWELEQRKRLAEQYKTSLSSK-EKIQKAIEQKREYLSSLQPGLHNIMQASLPVQEYLSMPFEHM 275

  Fly   198 WKLSAVVKYLPKPLYVLFIVLQSLQRVSEEQSFTAEVVGYESEAQMQELLKEKKCSTLNYRQTKK 262
            .|.:.|.::||.||||||:...:..:.. :::.|..:.|...||         |..:.....::.
Zfish   276 QKQAEVARHLPPPLYVLFVQAGAYGQAC-DKNLTVSIRGDVDEA---------KALSRPPEDSQD 330

  Fly   263 ESGDREKIADKNN-----------LDDS----LAPHPLHICLTIGAAGSNQLVLQIRYFDFIKCA 312
            :..|.:...::.|           |||.    |..|||.:.:.:.....:.|.|...|...:...
Zfish   331 DESDSDAEEEQQNTKRRRPTVGVQLDDKRKEMLRRHPLSLGIDLKCKDGSVLHLYFYYLMNLNIL 395

  Fly   313 TVWGQLNCSRNANG---QGDTNFVHHLLRHLYPNDLGNELPIPGIQYELRSSDLTAEECVRYLKA 374
            ||..:::.|.:.:|   .|:......||..||.:|.|||.|.|..:|:.....:|.  ...|:
Zfish   396 TVKTKVSTSVDLSGAISAGELLNSESLLNCLYASDHGNETPNPANRYQFDKVGITT--FADYV-- 456

  Fly   375 KDYGKPFCWLQSMCSIATVNSSMLYKHELN---LNKNNKEIIDRIAR-RLNSWQRLSQQIRGLTF 435
            .|.|.|:.|:|.:..:..  ||...:.||:   |:.::.|...::.| ||.|...|.:|...|..
Zfish   457 SDLGHPYVWVQKLSGLQF--SSDAAQSELSGSALSASHMEKSMKLLRGRLQSRLALHKQFSSLEH 519

  Fly   436 KDIDLYSLQENIYPAGLSCSLVQWTAITHEELH--SQISDALNSSSADKGITYNSYRAVIVRGSA 498
            ..:.:.|..::::||.:...|.:||.::|:|..  |.:...|.:....:  |...::||:.||:|
Zfish   520 SIVPVSSECQHLFPAKVVSGLTRWTMMSHQEFTELSFVQHVLKAGLVSE--TDLFFKAVVERGTA 582

  Fly   499 KMECFIRIPSNYPLEMPLWILNVHWNGCLTAQNNSAIKMMEFWTN----SLQ-PKHLEPNDCILY 558
            ::...:.:...||...||:.|::.|.|..:.:.:..::.||...|    .|| |:   |...:|.
Zfish   583 RLLAAVVVNPRYPEVTPLFSLSLLWKGERSGRTDDNLRAMESEVNVFRAELQGPR---PGLQLLT 644

  Fly   559 AQLFRTIYSFDIFLETEGSM----QNTIEYNKEKPYISAFAKRSRSRPYKY 605
            .|:.|.....|::||||..:    :...|:.:||..:......||.:|:||
Zfish   645 NQIQRLCMCLDVYLETESQVSDGSEGPKEFPREKMCLRTARGPSRLKPFKY 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
thoc5	NP_611856.1	FimP	42..392	CDD:286807	114/371 (31%)
thoc5	XP_005174290.1	FimP	118..474	CDD:286807	114/377 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580293
Domainoid	1	1.000	146	1.000	Domainoid score	I4502
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37836
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3649
OMA	1	1.010	-	-		QHG52356
OrthoDB	1	1.010	-	-		D1048314at2759
OrthoFinder	1	1.000	-	-		FOG0004183
OrthoInspector	1	1.000	-	-		oto40882
orthoMCL	1	0.900	-	-		OOG6_103875
Panther	1	1.100	-	-	LDO	PTHR13375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4566
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910