Protein Alignment fzr2 and CDC20

DIOPT Version :10

• Sequence 1: NP_611854.1
• Gene: fzr2 / 37808
• FlyBaseID: FBgn0034937
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_001246.2
• Gene: CDC20 / 991
• HGNCID: 1723
• Length: 499
• Species: Homo sapiens
• Alignment Length: 468
• Identity: 168/468 - (35%)
• Similarity: 248/468 - (52%)
• Gaps: 52/468 - (11%)

  Fly    12 PGVAVGKKEDIDLRCIPTRAGNHWNRNFVNAPGDSNVYESS-----VYSCLLRNEFLDENITSLE 71
            ||...||... .::..|::.|           ||..:...|     |.|.||..|...||..:..
Human    56 PGRTPGKSSS-KVQTTPSKPG-----------GDRYIPHRSAAQMEVASFLLSKENQPENSQTPT 108

  Fly    72 NCEQTAQVHAQTDDFRDRHNRIFGFASGSSSPVRTPFANISESSQRLLSIF----------KRPM 126
            ..|.........:.|.....:|...   |..|...|     |..|..|.:.          ::..
Human   109 KKEHQKAWALNLNGFDVEEAKILRL---SGKPQNAP-----EGYQNRLKVLYSQKATPGSSRKTC 165

  Fly   127 RRLPRRPYKILDAPELQDDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLIT 191
            |.:|..|.:||||||:::|:||||:||||.|.|||.|..|||||||.||.:.:|.........|:
Human   166 RYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYIS 230

  Fly   192 AVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWCGNRLASGSRDRSILQRDI 256
            :|:|..||..:|:||.|..|.:||.:.||::..:..|||||.:|:|....|:||||...|...|:
Human   231 SVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDV 295

  Fly   257 RNPPTHITRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTD-----DWPEPIYAFDEHKAVV 316
            |....|:. .|.||..|||||:|:|..|:|||||:||.:.||..     .| .|:..|.:|:..|
Human   296 RVAEHHVA-TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW-VPLQTFTQHQGAV 358

  Fly   317 KALGWSPHKSGLLASGGGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQP 381
            ||:.|.|.:|.:||:|||::||.:|.|||.:|..:..::..:|:.::.|:...:||::.||.||.
Human   359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQN 423

  Fly   382 QVIAWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVF--------TKQKISK 438
            |::.|:||::.::|.|.|||.|||.|::|||..::.:..||||||.|..|        .::|.|.
Human   424 QLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASA 488

  Fly   439 EPNSVLRLFKGIR 451
            ..:|::.  :|||
Human   489 AKSSLIH--QGIR 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40 repeat	149..185	CDD:293791	21/35 (60%)
		WD40	<159..436	CDD:441893	118/289 (41%)
		WD40 repeat	190..227	CDD:293791	14/36 (39%)
		WD40 repeat	233..269	CDD:293791	12/35 (34%)
		WD40 repeat	274..310	CDD:293791	18/40 (45%)
		WD40 repeat	317..355	CDD:293791	17/37 (46%)
		WD40 repeat	360..398	CDD:293791	12/37 (32%)
		WD40 repeat	404..436	CDD:293791	14/39 (36%)
CDC20	NP_001246.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..80		8/35 (23%)
		WD 1	182..221		24/38 (63%)
		WD40 repeat	188..224	CDD:293791	21/35 (60%)
		WD40	<190..471	CDD:441893	121/282 (43%)
		WD 2	224..263		14/38 (37%)
		WD40 repeat	229..266	CDD:293791	14/36 (39%)
		WD 3	266..303		16/36 (44%)
		WD40 repeat	272..307	CDD:293791	12/35 (34%)
		WD 4	307..346		20/39 (51%)
		WD40 repeat	312..352	CDD:293791	18/40 (45%)
		WD 5	353..395		19/41 (46%)
		WD40 repeat	359..397	CDD:293791	17/37 (46%)
		WD 6	397..438		12/40 (30%)
		WD40 repeat	402..440	CDD:293791	12/37 (32%)
		WD 7	441..480		18/38 (47%)