DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and AMA1

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_011741.5	Gene:	AMA1 / 853140	SGDID:	S000003457	Length:	593	Species:	Saccharomyces cerevisiae

Alignment Length:	462	Identity:	132/462 - (28%)
Similarity:	216/462 - (46%)	Gaps:	101/462 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EFLDENITSLENCEQTAQVHAQTDDFRDRHNRIFGFASGSSSPVRTPF--------------ANI 111
            |.|::| .:::||                      |..||.:.:|:.|              ||.
Yeast   152 EILEKN-KAIKNC----------------------FGPGSCAEIRSTFDFSTLSPDVARYYIANS 193

  Fly   112 ---SESSQRLLSIFKRPMRRLPRR-PYKILDAPELQDDFYLNLIDWS-SKNTLAVGLGCSVYLWS 171
               |.|.||.:   :||.:|:... ||::||||.|::|||.|||.|| :.|.:.||||||||:||
Yeast   194 NARSASPQRQI---QRPAKRVKSHIPYRVLDAPCLRNDFYSNLISWSRTTNNVLVGLGCSVYIWS 255

  Fly   172 AVSGQVTRLCD--FNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAE--------NQKQ---IN 223
            ...|.|:.|..  .:.:.:|:|.||:........:||:.|.:.::|.:        |:|:   :.
Yeast   256 EKEGAVSILDHQYLSEKRDLVTCVSFCPYNTYFIVGTKFGRILLYDQKEFFHSSNTNEKEPVFVF 320

  Fly   224 RLEEHSARVTALAW------CGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKLE--------- 273
            :.|.... :..|.|      |  :...|..:.::...:|::....|....:..|||
Yeast   321 QTESFKG-ICCLEWFKPGEIC--KFYVGEENGNVSLFEIKSLHFPIKNWSKRQKLEDENLIGLKL 382

  Fly   274 ----------VCGLQWSPSNRYLASGGSDNRLLVW-TDDWPEPIYAFD-EHKAVVKALGWSPHKS 326
                      |||:..:.....||.||:||...:| ..|..:||..|. .|||.|||:.:.|...
Yeast   383 HSTYQAQAQQVCGISLNEHANLLAVGGNDNSCSLWDISDLDKPIKKFVLPHKAAVKAIAFCPWSK 447

  Fly   327 GLLASGGGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQ----VIAWR 387
            .|||:||||.|||::||:..||.|:..|.|..|:::|.|:...:::|.|.|....:    :..:.
Yeast   448 SLLATGGGSKDRCIKFWHTSTGTLLDEICTSGQVTSLIWSLRHKQIVATFGFGDTKNPVLITLYS 512

  Fly   388 YPSLKQMARL-SGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFT-KQKISKE-------PNSV 443
            ||.|.::..: |.:..|||...:||.:.:|.....|||:||:.::. |::|..|       .:::
Yeast   513 YPKLSKLLEVRSPNPLRVLSAVISPSSMAICVATNDETIRFYELWNDKEEIINEIQESGIYGSNI 577

  Fly   444 LRLFKGI 450
            :...:||
Yeast   578 IEYMEGI 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	121/402 (30%)
		WD40 repeat	149..185	CDD:293791	19/38 (50%)
		WD40	190..446	CDD:295369	81/306 (26%)
		WD40 repeat	190..227	CDD:293791	9/47 (19%)
		WD40 repeat	233..269	CDD:293791	6/41 (15%)
		WD40 repeat	274..310	CDD:293791	13/36 (36%)
		WD40 repeat	317..355	CDD:293791	18/37 (49%)
		WD40 repeat	360..398	CDD:293791	8/42 (19%)
		WD40 repeat	404..436	CDD:293791	11/32 (34%)
AMA1	NP_011741.5	WD40 repeat	234..271	CDD:293791	17/36 (47%)
		WD40	266..561	CDD:421866	79/297 (27%)
		WD40 repeat	276..321	CDD:293791	9/44 (20%)
		WD40 repeat	328..374	CDD:293791	8/47 (17%)
		WD40 repeat	394..432	CDD:293791	13/37 (35%)
		WD40 repeat	437..474	CDD:293791	19/36 (53%)
		WD40 repeat	482..523	CDD:293791	8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770