DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and CDC20

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_011399.1	Gene:	CDC20 / 852762	SGDID:	S000003084	Length:	610	Species:	Saccharomyces cerevisiae

Alignment Length:	330	Identity:	119/330 - (36%)
Similarity:	182/330 - (55%)	Gaps:	16/330 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 ESSQRLLSIFKRPMRRLPRRPYKILDAPELQDDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQV 177
            :..|::..:.|  :|::...|.:|||||..||||||||:.||.||.||:.|..::|||:|.:|.|
Yeast   231 QQEQKIPDLIK--LRKINTNPERILDAPGFQDDFYLNLLSWSKKNVLAIALDTALYLWNATTGDV 293

  Fly   178 TRLCDFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEH-SARVTALAWCGNR 241
            :.|.||  |:..|.:|:|..:...::||.:.|...|||.|....|..:... ..|:.:|:|....
Yeast   294 SLLTDF--ENTTICSVTWSDDDCHISIGKEDGNTEIWDVETMSLIRTMRSGLGVRIGSLSWLDTL 356

  Fly   242 LASGSRDRSILQRDIRNPPTHITRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPI 306
            :|:|||...|...|:| ...||......|..|||||.:......|||||:||.:::|......|.
Yeast   357 IATGSRSGEIQINDVR-IKQHIVSTWAEHTGEVCGLSYKSDGLQLASGGNDNTVMIWDTRTSLPQ 420

  Fly   307 YAFDEHKAVVKALGWSPHKSGLLASGGGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARD--- 368
            ::...|.|.||||.|.|:...:||||||..|:.:.|||.:||..|..||||:|:|:|.|.:.
Yeast   421 FSKKTHTAAVKALSWCPYSPNILASGGGQTDKHIHFWNSITGARVGSINTGSQVSSLHWGQSHTS 485

  Fly   369 ------SRELVTTHGHAQPQVIAWRYPSLKQMAR-LSGHTQRVLHLSVSPDNESIVTGGADETLR 426
                  ::|:|.|.|:.:..:..:.|.:..::|. :..|..|:....:|||..::.|.|.||.|:
Yeast   486 TNGGMMNKEIVATGGNPENAISVYNYETKFKVAEVVHAHEARICCSQLSPDGTTLATVGGDENLK 550

  Fly   427 FWTVF 431
            |:.:|
Yeast   551 FYKIF 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	119/330 (36%)
		WD40 repeat	149..185	CDD:293791	18/35 (51%)
		WD40	190..446	CDD:295369	85/253 (34%)
		WD40 repeat	190..227	CDD:293791	11/36 (31%)
		WD40 repeat	233..269	CDD:293791	11/35 (31%)
		WD40 repeat	274..310	CDD:293791	13/35 (37%)
		WD40 repeat	317..355	CDD:293791	18/37 (49%)
		WD40 repeat	360..398	CDD:293791	9/47 (19%)
		WD40 repeat	404..436	CDD:293791	10/28 (36%)
CDC20	NP_011399.1	WD40	<240..560	CDD:225201	118/321 (37%)
		WD40 repeat	265..301	CDD:293791	18/37 (49%)
		WD40 repeat	304..340	CDD:293791	11/35 (31%)
		WD40 repeat	348..381	CDD:293791	11/33 (33%)
		WD40 repeat	388..422	CDD:293791	13/33 (39%)
		WD40 repeat	430..476	CDD:293791	24/45 (53%)
		WD40 repeat	528..562	CDD:293791	10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810