DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and CDC20.5

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_198109.2	Gene:	CDC20.5 / 832817	AraportID:	AT5G27570	Length:	450	Species:	Arabidopsis thaliana

Alignment Length:	447	Identity:	155/447 - (34%)
Similarity:	236/447 - (52%)	Gaps:	61/447 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KEDIDLRCIPTRAGNHWN-RNFVNAPGDSNVYESSVYSCLLRNEFLDENITSLENCEQTAQVHAQ 82
            ||:.| |.||.|:...:: .|:....|..                  .|:..:.:..:.|.:...
plant    27 KENFD-RFIPNRSAMDFDFANYALTQGRK------------------RNVDEVTSASRKAYMTQL 72

  Fly    83 TDDFRDRHNRIFGF--------ASGSSSPVRTPFANISESSQRLLSIFKRPMRRLPRRPYKILDA 139
            .:.......||..|        :|..|.|          ..|:.:|:  :|.|.:|:...::|||
plant    73 AEAMNQNRTRILAFRNKPKALLSSNHSDP----------PHQQPISV--KPRRYIPQNSERVLDA 125

  Fly   140 PELQDDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAI 204
            |.:.|||||||:||.|.|.||:.||.:||||.|.||...:|...:.|:..:|:::|..:|..:||
plant   126 PGIADDFYLNLLDWGSSNVLAIALGDTVYLWDASSGSTYKLVTIDEEEGPVTSINWTQDGLDLAI 190

  Fly   205 GTQSGYVTIWDAENQKQINRLE-EHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLR 268
            |..:..|.:||..:.:|:..|. .|.:||.:|||..:.|.:|..|..|:..|:| ..:.|.....
plant   191 GLDNSEVQLWDCVSNRQVRTLRGGHESRVGSLAWNNHILTTGGMDGKIVNNDVR-IRSSIVETYL 254

  Fly   269 GHKLEVCGLQWSPSNRYLASGGSDNRLLVW----------TDDWPEPIYAFDEHKAVVKALGWSP 323
            ||..|||||:||.|.:.|||||:||.:.:|          |..|   ::.|:||.|.|:||.|.|
plant   255 GHTEEVCGLKWSESGKKLASGGNDNVVHIWDHRSVASSNPTRQW---LHRFEEHTAAVRALAWCP 316

  Fly   324 HKSGLLASGGGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRY 388
            .::.|||:|||..|..::|||..||..:..:.||:|:.:|.|::..|||:::||..|.|:..|:|
plant   317 FQASLLATGGGVGDGKIKFWNTHTGACLNSVETGSQVCSLLWSKSERELLSSHGFTQNQLTLWKY 381

  Fly   389 PSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVF------TKQKISKE 439
            ||:.:||.|:|||.|||.::.|||..::.:...|||||.|.||      ||:..||:
plant   382 PSMVKMAELNGHTSRVLFMAQSPDGCTVASAAGDETLRLWNVFGEPPKTTKKAASKK 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	139/354 (39%)
		WD40 repeat	149..185	CDD:293791	18/35 (51%)
		WD40	190..446	CDD:295369	105/267 (39%)
		WD40 repeat	190..227	CDD:293791	11/37 (30%)
		WD40 repeat	233..269	CDD:293791	10/35 (29%)
		WD40 repeat	274..310	CDD:293791	17/45 (38%)
		WD40 repeat	317..355	CDD:293791	16/37 (43%)
		WD40 repeat	360..398	CDD:293791	15/37 (41%)
		WD40 repeat	404..436	CDD:293791	15/37 (41%)
CDC20.5	NP_198109.2	WD40	<140..428	CDD:225201	116/291 (40%)
		WD40 repeat	177..214	CDD:293791	11/36 (31%)
		WD40 repeat	219..251	CDD:293791	11/32 (34%)
		WD40 repeat	261..303	CDD:293791	16/44 (36%)
		WD40 repeat	309..345	CDD:293791	17/35 (49%)
		WD40 repeat	353..391	CDD:293791	15/37 (41%)
		WD40 repeat	397..421	CDD:293791	10/23 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830