DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and CDC20.4

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_198042.1	Gene:	CDC20.4 / 832748	AraportID:	AT5G26900	Length:	444	Species:	Arabidopsis thaliana

Alignment Length:	438	Identity:	157/438 - (35%)
Similarity:	237/438 - (54%)	Gaps:	44/438 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KEDIDLRCIPTRAGNHWN-RNFVNAPGDSNVYESSVYSCLLRNEFLDENITSLENCEQTAQVHAQ 82
            |:::| |.||.|:...:: .|:....|..            ||  ||| :||........|:...
plant    22 KQNLD-RFIPNRSAKDFDFANYALTQGSK------------RN--LDE-VTSASRKAYMTQLAVV 70

  Fly    83 TDDFRDRHNRIFGFASGSSSPVRTPFANISESSQRLLSIFKRPMRRLPRRPYKILDAPELQDDFY 147
            .:..|   .||..|.:...|.:.|   |.|:|..:.....| |.|.:|:...::||||.|:|||.
plant    71 MNQNR---TRILAFRNKPKSLLST---NHSDSPHQNPKPVK-PRRYIPQNSERVLDAPGLRDDFS 128

  Fly   148 LNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQSGYVT 212
            |||:||.|.|.||:.||.:||||.|.||..:.|...:.:...:|:::|..:|..:|:|..:..|.
plant   129 LNLLDWGSANVLAIALGDTVYLWDASSGSTSELVTIDEDKGPVTSINWTQDGLDLAVGLDNSEVQ 193

  Fly   213 IWDAENQKQINRLE-EHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKLEVCG 276
            :||..:.:|:..|. .|.:||.:|||..:.|.:|..|..|:..|:| ..:.|.....||..||||
plant   194 LWDCVSNRQVRTLRGGHESRVGSLAWDNHILTTGGMDGKIVNNDVR-IRSSIVETYLGHTEEVCG 257

  Fly   277 LQWSPSNRYLASGGSDNRLLVW---------TDDWPEPIYAFDEHKAVVKALGWSPHKSGLLASG 332
            |:||.|....||||:||.:.:|         |..|   ::.|:||.|.|:||.|.|.::.|||:|
plant   258 LKWSESGNKQASGGNDNVVHIWDRSLASSKQTRQW---LHRFEEHTAAVRALAWCPFQASLLATG 319

  Fly   333 GGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMARL 397
            ||..|..::|||..||..:..:.||:|:.:|.|::..|||:::||..|.|:..|:|||:.:||.|
plant   320 GGVGDGKIKFWNTHTGACLNSVETGSQVCSLLWSQSERELLSSHGFTQNQLTLWKYPSMSKMAEL 384

  Fly   398 SGHTQRVLHLSVSPDNESIVTGGADETLRFWTVF------TKQKISKE 439
            :|||.|||.::.||:..::.:...||.||.|.||      ||:..||:
plant   385 NGHTSRVLFMAQSPNGCTVASAAGDENLRLWNVFGEPPKTTKKAASKK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	136/353 (39%)
		WD40 repeat	149..185	CDD:293791	18/35 (51%)
		WD40	190..446	CDD:295369	101/266 (38%)
		WD40 repeat	190..227	CDD:293791	10/37 (27%)
		WD40 repeat	233..269	CDD:293791	10/35 (29%)
		WD40 repeat	274..310	CDD:293791	16/44 (36%)
		WD40 repeat	317..355	CDD:293791	16/37 (43%)
		WD40 repeat	360..398	CDD:293791	15/37 (41%)
		WD40 repeat	404..436	CDD:293791	13/37 (35%)
CDC20.4	NP_198042.1	WD40	<147..422	CDD:225201	105/278 (38%)
		WD40 repeat	172..209	CDD:293791	10/36 (28%)
		WD40 repeat	214..246	CDD:293791	11/32 (34%)
		WD40 repeat	256..296	CDD:293791	15/42 (36%)
		WD40 repeat	303..339	CDD:293791	17/35 (49%)
		WD40 repeat	347..385	CDD:293791	15/37 (41%)
		WD40 repeat	391..415	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830