DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and CDC20.2

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_195052.1	Gene:	CDC20.2 / 829462	AraportID:	AT4G33260	Length:	447	Species:	Arabidopsis thaliana

Alignment Length:	460	Identity:	168/460 - (36%)
Similarity:	263/460 - (57%)	Gaps:	43/460 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QQRLLPGVAVGKKEDIDLRCIPTRAGNHWNRNFVNAPGDSNVYESSVYSCLLRNEFLDENIT-SL 70
            |:..||  ....||::| |.||       ||:.:|       ::.:.::.....:..|::.| |.
plant    11 QEHFLP--RKNSKENLD-RFIP-------NRSAMN-------FDYAHFALTEERKGKDQSATVSS 58

  Fly    71 ENCEQTAQVHAQTDDFRDRHNRIFGFASGSSSPVRTPFANISES-SQRLLSIFKRPMRRLPRRPY 134
            .:.|...:..|:|.:.  .|.||..|.:...:||....:|.|.| .|:..|:  :|.|.:|:...
plant    59 PSKEAYRKQLAETMNL--NHTRILAFRNKPQAPVELLPSNHSASLHQQPKSV--KPRRYIPQTSE 119

  Fly   135 KILDAPELQDDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEG 199
            :.||||::.|||||||:||.|.|.||:.|..:||||.|.:|..:.|...:.|...:|:::|..:|
plant   120 RTLDAPDIVDDFYLNLLDWGSANVLAIALDHTVYLWDASTGSTSELVTIDEEKGPVTSINWAPDG 184

  Fly   200 RQVAIGTQSGYVTIWDAENQKQINRLE-EHSARVTALAWCGNRLASGSRDRSILQRD--IRNPPT 261
            |.||:|..:..|.:||:.:.:|:..|: .|.:||.:|||..:.|.:|..|..|:..|  ||:|
plant   185 RHVAVGLNNSEVQLWDSASNRQLRTLKGGHQSRVGSLAWNNHILTTGGMDGLIINNDVRIRSP-- 247

  Fly   262 HITRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVW---------TDDWPEPIYAFDEHKAVVK 317
             |....|||..|||||:||.|.:.|||||:||.:.:|         |..|   ::..:||.:.||
plant   248 -IVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRSVASSNSTTQW---LHRLEEHTSAVK 308

  Fly   318 ALGWSPHKSGLLASGGGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQ 382
            ||.|.|.::.|||:|||..||.::|||..||..:..::||:|:.:|.|:::.|||:::||..|.|
plant   309 ALAWCPFQANLLATGGGGGDRTIKFWNTHTGACLNSVDTGSQVCSLLWSKNERELLSSHGFTQNQ 373

  Fly   383 VIAWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFTKQKISKE--PNSVLR 445
            :..|:|||:.:||.|:|||.|||:::.|||..::.:...|||||||.||...:.:|:  |.:|..
plant   374 LTLWKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWNVFGVPETAKKAAPKAVAE 438

  Fly   446 LFKGI 450
            .|..:
plant   439 PFSHV 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	142/350 (41%)
		WD40 repeat	149..185	CDD:293791	16/35 (46%)
		WD40	190..446	CDD:295369	109/269 (41%)
		WD40 repeat	190..227	CDD:293791	12/37 (32%)
		WD40 repeat	233..269	CDD:293791	12/37 (32%)
		WD40 repeat	274..310	CDD:293791	17/44 (39%)
		WD40 repeat	317..355	CDD:293791	18/37 (49%)
		WD40 repeat	360..398	CDD:293791	15/37 (41%)
		WD40 repeat	404..436	CDD:293791	14/31 (45%)
CDC20.2	NP_195052.1	WD40	<139..425	CDD:225201	119/291 (41%)
		WD40	149..420	CDD:238121	111/276 (40%)
		WD40 repeat	175..212	CDD:293791	12/36 (33%)
		WD40 repeat	219..254	CDD:293791	12/37 (32%)
		WD40 repeat	259..301	CDD:293791	17/44 (39%)
		WD40 repeat	308..346	CDD:293791	18/37 (49%)
		WD40 repeat	351..389	CDD:293791	15/37 (41%)
		WD40 repeat	395..421	CDD:293791	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830