DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and FZR2

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_194022.3	Gene:	FZR2 / 828390	AraportID:	AT4G22910	Length:	483	Species:	Arabidopsis thaliana

Alignment Length:	448	Identity:	205/448 - (45%)
Similarity:	271/448 - (60%)	Gaps:	55/448 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RCIPTRAGNHWNRNFV------NAPGDSNVYESSVYSCLLRNEFLDENITSLENCEQTAQVHAQT 83
            |.||:|:|:    ||.      :...|.....:..|:.|||                .|....:|
plant    63 RFIPSRSGS----NFALFDLSPSPSKDGKEDGAGSYATLLR----------------AAMFGPET 107

  Fly    84 DDFRDRHNRIFGFASGSSSPVRTPFANISESSQRLLSI-----------------FKRPMRRLPR 131
            .:.||    |.||:|.     |..|...:|:.:.|.|.                 .|.| |::||
plant   108 PEKRD----ITGFSSS-----RNIFRFKTETHRSLNSFSPFGVDDDSPGVSHSGPVKAP-RKVPR 162

  Fly   132 RPYKILDAPELQDDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWH 196
            .|||:||||.|||||||||:|||::|.||||||..||||:|.|.:||:|||...||: :.:|.|.
plant   163 SPYKVLDAPALQDDFYLNLVDWSAQNVLAVGLGNCVYLWNACSSKVTKLCDLGAEDS-VCSVGWA 226

  Fly   197 GEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPT 261
            ..|..:|:||.:|.|.||||...|:...:|.|..||.||||..:.|:|||||:||||||||....
plant   227 LRGTHLAVGTSTGKVQIWDASRCKRTRTMEGHRLRVGALAWGSSVLSSGSRDKSILQRDIRCQED 291

  Fly   262 HITRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKS 326
            |::: |.|||.|||||:||..||.|||||:||||.||.....:|:..:.||.|.|||:.||||..
plant   292 HVSK-LAGHKSEVCGLKWSYDNRELASGGNDNRLFVWNQHSTQPVLKYSEHTAAVKAIAWSPHVH 355

  Fly   327 GLLASGGGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSL 391
            ||||||||:||||:||||..|...:..|:|.:|:.||||:::..|||:|||::|.|:|.|:||::
plant   356 GLLASGGGTADRCIRFWNTTTNTHLSSIDTCSQVCNLAWSKNVNELVSTHGYSQNQIIVWKYPTM 420

  Fly   392 KQMARLSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFTKQKISKEPNSVLRLFKG 449
            .::|.|:|||.|||:|:||||.::||||..|||||||.||...|.....:.:...|.|
plant   421 SKIATLTGHTYRVLYLAVSPDGQTIVTGAGDETLRFWNVFPSPKSQNTDSEIGSSFFG 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	183/354 (52%)
		WD40 repeat	149..185	CDD:293791	23/35 (66%)
		WD40	190..446	CDD:295369	134/255 (53%)
		WD40 repeat	190..227	CDD:293791	13/36 (36%)
		WD40 repeat	233..269	CDD:293791	20/35 (57%)
		WD40 repeat	274..310	CDD:293791	20/35 (57%)
		WD40 repeat	317..355	CDD:293791	23/37 (62%)
		WD40 repeat	360..398	CDD:293791	17/37 (46%)
		WD40 repeat	404..436	CDD:293791	20/31 (65%)
FZR2	NP_194022.3	WD40	182..458	CDD:421866	153/277 (55%)
		WD40 repeat	220..257	CDD:293791	13/36 (36%)
		WD40 repeat	263..298	CDD:293791	20/35 (57%)
		WD40 repeat	303..339	CDD:293791	20/35 (57%)
		WD40 repeat	346..384	CDD:293791	23/37 (62%)
		WD40 repeat	389..427	CDD:293791	17/37 (46%)
		WD40 repeat	433..459	CDD:293791	18/25 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1507
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.890